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Oxidative Stress

Decent Essays
Module ten discussed oxidative stress, and the causes, as well as consequences of liver disorders. Oxidative stress occurs when there is an abnormal balance between nonspecific oxidation reactions, and the body's ability to counteract them. A nonspecific oxidation reaction refers to one that involves free radicals reacting in a disorderly fashion with other molecules. Free radicals are highly reactive molecules that can cause cellular damage, targeting that of carbohydrates, lipids, proteins and nucleic acids. Free radicals within the body can lead to fragmentation of proteins causing them to have an abnormal function, oxidize polysaturated lipids at their double bond causing disruption in the membrane function, and cause mutations in DNA. Antioxidants react directly with free radicals in the body to render them inactive. Some antioxidant…show more content…
Glutathione and uric acid are antioxidants that are made by the cells. Glutathione performs most of its antioxidant activity within the cell, while uric acid does most of its antioxidant activity in the blood plasma. The antioxidants, which can be obtained from the diet, include vitamin C, vitamin E, carotenoids and selenium. The liver disorders discussed were that of a fatty liver and alcoholic liver disease. A fatty liver is a disorder that is characterized by the accumulation of triglycerides within liver cells, causing the liver to enlarge up to three times its normal size. The accumulation of triglycerides in the liver will cause the liver to have a yellow appearance. A fatty liver can be caused several ways, such as obesity, protein energy malnutrition, metabolic disorders, and chronic alcohol consumption. The treatment for a fatty liver depends on the cause for the fatty liver. For example, if a fatty liver is caused by chronic alcohol consumption, then the patient would need to stop consuming alcohol in order to reverse the damage.
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