P Gingivalis Synthesis

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Fourthly, the fermentation end products of P. gingivalis, such as acetic acid, propionic acid and butyric acid, and volatile sulfur compounds produced in large quantities can stimulate cytotoxic effect on the host cells. Most P. gingivalis strains are able to produce capsular polysaccharides. Those polysaccharides reduce binding of P. gingivalis to PMN and inhibited phagocytosis. Lipopolysaccharide (LPS) present in the cell wall plays the role of the antigen and activates cytokines (15). Prevotella intermedia has a unique hemolytic activity. Proteases produced by Prevotella can destroy a number of proteins involving collagen and fibronectin. It has been shown that proteases possess trypsin-like properties that characterize mainly cysteine…show more content…
Experimental studies show that the S layer of these species may provide their adherence to host cells, and invasiveness. Meanwhile, they produce their pathogenicity by production of enzymes like trypsin-like protease (PrtH), and glycosidase. Their metabolic products of the fermentation of, such as acetic acid, propionic acid and butyric acid are cytotoxic on host cells (18). Strains of the Treponema denticola species are the spiral bacteria, characterized by an active movement. So they have the ability to migrate and penetrate into undamaged periodontal tissue (19).
Strains of Lactobacillus species are also microhabitats in the periodontal tissues, (including L. reuteri, L. acidophilus, L. brevis) and are in contrast have an important role in prevention of progression of chronic periodontitis. Oral lactobacilli may restrict development of inflammatory lesions in chronic periodontitis. They are producing oral H2O2 that prevent the progress of chronic periodontitis, most probably restricting secretory activity of Th1 7 cells and growth of period onto
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