PD Parkinson's Disease

Neurology is one of the most unexplored fields in medicine; however, more recently there has been a spike in the amount of research being done in this specialty. This is because people are becoming more interested in neuroscience, including myself. I attended a pre-medical vocational high school, which exposed me to a greater amount of knowledge pertaining to the basics of anatomy and physiology, along with hands-on opportunities in a medical setting. It was here where I realized that I wanted to pursue a career in medicine; however, due to the fact medical field is very broad, I had no set specialty. This changed when I was exposed to the cruel manifestations of Parkinson’s Disease. During, sophomore year of high school, my grandfather passed away due to complications of Parkinson’s Disease. The way that a neurodegenerative disease was able to overtake a person in the manner that it did was shocking, and while it brought me great grief initially, it later intrigued me. I took up an interest in neuroscience and began to do my own research which culminated in various projects and applications throughout the remainder of my time in high school. These experiences have culminated in my decision to work toward a Cell Biology and

Each year more than 60,000 Americans are diagnosed with Parkinson’s disease (PDF, 2014). That sixty thousand does not include the many thousand cases that go undetected each year. Parkinson’s is a progressive disorder that occurs in the nervous system. This disease affects a person’s movement. Parkinson’s disease develops progressively. The most common first sign of Parkinson’s is slight shaking of a body part. In the initial phase of Parkinson’s a person will experience slurring of speech and an expressionless face (Mayo Clinic, 2014). With time, the symptoms of Parkinson’s exacerbate. This disease is most frequently seen in people over the age of 50 (PDF, 2014). Parkinson’s disease is generated by a great number of reasons.

Parkinson disease (PD) is one of the most common neurologic disorders. and it affects approximately 1% of individuals older than 60 years old. Parkinson’s disease is a condition that progresses slowly by treatment. In addition, loss of pigmented dopaminergic neurons of the substantianigra pars compacta and the presence of Lewy bodies and Lewyneurites are the two major neuropathologic findings in Parkinson disease (Hauser, 2016).

By the time someone shows signs and symptoms of Parkinson 's, Dopamine production in the brain has been reduced by 60 to 80% and is fairly advanced. This results in the most recognizable sign of Parkinson 's disease, the resting tremor of the hand or hands. During deliberate movement, the resting tremor goes away, at first. At rest, the tremor will become exacerbated,

In the past twenty years, many drugs have been developed to treat the disease. Although the cause of Parkinson's disease is still unknown, scientists have been developing methods of treatment and therapy. The idea is to replace dopamine in the brain, which is accomplished, to some extent, with the administration of L-Dopa. In conjunction with other drugs, L- Dopa "inhibits the enzymes that break down L-dopa in the liver, thus making a greater part of it available to the brain" (5). This treatment is very successful, but it only hinders the disease for a time and it is by no means a cure. That leaves us with stem-cells and the role they play in treatment of Parkinson's disease.

The major component shared by both Parkinson’s disease and dementia is the functioning of neurons, with a then understandable association. Dementia is caused by neuron demise or diminished capacity of communication with other cells, while Parkinson’s disease, neurons in the basal ganglia experience deterioration that disrupts the normal neurotransmitter dopamine balance where neurons waste and die. With this shared neuron deterioration, the prevalence of dementia associated with Parkinson’s disease is clearly understood. One-third of all patients with Parkinson’s disease will display dementia (LeMone, Burke, & Bauldoff, 2011) with indicators identical to Alzheimer’s form of dementia.

Parkinson's disease affects the way you move. It happens when there is a problem with certain nerve cells in the brain. Normally, these nerve cells make an important chemical called dopamine. Dopamine sends signals to the part of your brain that controls movement. Some conspiracy theories makes us happy by creating a picture where hitler was finally reduced to a trembling, almost rigid person with the mood swings of a woman at her worst PMS, shambling through a burnt, destroyed, and pillaged Nazi regime because he was inflicted by parkinson's disease in the final days of his life. Although it is rumored that hitler really had this disease. It was highly unlikely that he died from it due to the fact that parkinson's disease does not kill by

When people hear the words Parkinson’s disease they think, “Isn’t that what Michael J. Fox has?” For those who are asking, “Who is Michael J. Fox?” He was the character Marty McFly in the “Back to the Future” movie and played on many TV shows. After being diagnosed with Parkinson’s disease, he set up an organization to research Parkinsonism. What the Michael J. Fox Foundation found was that 40 percent of the people living with Parkinson’s disease experience dystonia as an early symptom or a complication of treatment. This is the only blurb you see on the website about dystonia. In fact, it is so much like the other disorders out there that many people have never heard of it. The purpose of this paper is to inform

While aging does not harm a person Its effects can devastate families, children, and acquaintances. 3 of the most well-known effects of Aging Are Parkinson's, alzheimers, and dementia. Well both diseases can take a toll on a person, they each take a different part of a person. Parkinson's effects the inner workings of the brain causing tremors And cannot be cured. Dementia is a disease that eats away at a senior citizens memory, many elderly patients have died due to the fact they forgot how to swallow and choke on their own saliva. Dementia is also linked to forgetfulness in senior citizens because it does interfere with daily living and functionality in their daily lives. Well all three diseases are very different they all do

Parkinson’s is a progressive neurodegenerative disease, primarily affecting voluntary, precise, and controlled movement. Parkinson’s occurs when cells in a part of the brain called the substantia nigra die off. These cells are responsible for producing dopamine. With less and less dopamine, a person has less and less ability to regulate their movements, body and emotions. The terms "familial Parkinson's disease" and "sporadic Parkinson's disease" are used to differentiate genetic from truly idiopathic forms of the disease.

Although the etiology of idiopathic Parkinson's disease (PD) is unknown, it is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) of ventral midbrain region [9]; [1]. Its prevalence is associated with age. Approximately 1% of the population is affected at 65–70 years of age, which increases to 4–5% in 85-year-olds [2]. Various epidemiological studies and pathological analyses have demonstrated that mean age of onset in sporadic PD, which accounts for about 95% of cases of Parkinsonism is 70 years [7]; [3]. Familial form of Parkinson’s disease is linked to genetic mutations and has prevalence rate of 4%. Familial Parkinson’s disease patients develop early-onset disease before the age of 50

Parkinson’s disease, Huntington's disease, and Alzheimer’s disease are neurodegenerative disorders that share similar pathological features, including delayed onset, specific neurological damage, and protein dysfunction [1]. Over the past decade, the increasing prevalence of these disorders is apparent. Although the advanced research into these pathogeneses has identified related genetic mutations, the progression to which they link is too slow to reveal the underlying mechanism and correspondent treatment [2]. Today, the emergence of induced pluripotent stem cell (iPSC) technology has made a breakthrough in the recent neurological research and overcome the hurdles met by cellular and animal models.

To be honest, Parkinson’s disease scares me; the eventuality of being frozen inside of my own body is terrifying. I have a customer that has shopped with us for at least the past seven years. I can remember when his hands started to shake so badly that he would just hold his coin purse out to me to select his change for him. Now he can’t even remove his own wallet from his back pocket. He will turn around and I pull out his wallet, take out his money or credit card to complete his transaction and then put his wallet back into his back pocket. We don’t talk about it and I try to act like I don’t even notice it, but I do and it’s terrifying.

Parkinson’s disease is affected by the degeneration of dopaminergic neurons which is responsible to produce dopamine. Dopaminergic neurons have their cell bodies in substantia nigra pars compacta (SNpc) in basal ganglia (O’Sullivan and Schmitz, 2007). Basal ganglia are a collection of interconnected gray matter nuclear masses deep within the brain”. These gray matter masses are caudate, putamen, globus pallidus, subthalamic nucleus and the substantia nigra. Basal ganglia receive its input through striatum (O’Sullivan and Schmitz, 2007).

Parkinson disease (PD) is a progressive neurodegenerative disorder characterized mainly by physical and psychological disabilities. This disorder was named after James Parkinson, an English physician who first described it as shaking palsy in 1817 (Goetz, Factr, and Weiner, 2002). Jean- Martin Charcot, who was a French neurologist, then progressed and further refined the description of the disease and identified other clinical features of PD (Goetz, Factr, and Weiner, 2002). PD involves the loss of cells that produce the neurotransmitter dopamine in a part of the brain stem called the substansia nigra, which results in several signs and symptoms (Byrd, Marks, and Starr, 2000). It is manifested clinically by tremor,