Statement of Purpose The purpose of this study is to test an intervention of dose adjustment on medication adherence and side effects of non-adherence in kidney transplant patients, specifically, to compare switching from a twice-daily dose of tacrolimus to a once-daily dose of tacrolimus, to improve medication adherence and prevent or reduce transplant rejection and graft loss in kidney transplant recipients. Clinicians play a vital role in helping patients make treatment decisions that are most beneficial for their health and values, making adjustments of medication dosages and educating patients on benefits, side effects, and adverse outcomes of these choices. Research Question A research question was developed to assess effects of …show more content…
Among kidney transplant recipients risk factors for non-adherence are health illiteracy, forgetfulness, frequency of dosing, medication changes, and complex medication regimens. Within overall transplant patients, non-adherence to immunosuppression therapy contributes to 20 percent of late acute rejection episodes and 16 percent of graft losses (Lieber, Helcer & Shemesh, 2014). In clinical practice, there is a absence of a systemic approach in identifying and treating non-adherence (Lieber, Helcer & Shemesh, 2014). Evidence is lacking in non-adherence studies that demonstrates a relationship between perceptions and medication adherence (Massey et al., 2015). A major limitation of these studies is that a cross-sectional design impedes causal relationships and investigation of changes over time (Massey et al., 2015). A better understanding of patient behaviors toward their immunosuppression medication, reasons for taking tacrolimus and any action that is reducing their pill intake is an important step for future actions proposed to improve adherence and transplant outcomes. According to Massey et al. (2015), some illness perceptions include the perceived cause or causes of the illness, timeline (acute, chronic or cyclical), identity or label that it is given, personal control over outcomes, effectiveness of treatment to control outcomes,
The pharmacist must offer to discuss the unique drug therapy regimen of each Medicaid recipient when filling prescriptions for them. Each patient must be made an offer to be counseled by the pharmacist. The items to be addressed include, the name of the drug, intended use of expected action, common side effects and their avoidance, techniques for self-monitoring, proper storage, potential drug-drug or drug-food contraindications, refill
Nonadherence to HTN treatment regimen leads to uncontrolled HTN; thus, leading to increased risk of morbidity. Furthermore, there is evidence that poor adherence to the treatment of HTN negatively affects the quality of life in patients diagnosed with the chronic disease (Hanus et al.,
Christianity assumes that our human nature is fundamentally and thoroughly flawed by sin, to the point where a divine miracle of grace is needed to allow us to trust Christ as Savior. Most people in Western cultures, however, do not consider themselves to be sinners and therefore feel no need for a Savior. Comment on this in the light of the detailed accounting rules and regulations intended to prevent investors from being defrauded, and the multi-billion dollar worldwide auditing profession that is intended to add credibility to financial statements.
This ultimately can affect mortality. About five percent of re-admissions are directly driven by lack of adherence to medications as prescribed by the healthcare providers. It is concerning for seniors as living costs continue to rise and their income fixed income remains stagnant.
This paper goes over the effects the media had on the O.J. Simpson case and how the media interfered. The O.J. Simpson murder case is touted as the most televised criminal trial in history and from the second the murders were discovered there was a media frenzy. On the night of June 12, 1994 the bodies of Nicole Brown and her waiter Ronald Goldman were found outside of Nicole’s condo both stabbed to death. The suspect, former athlete, icon, and actor Orenthal James (O.J.) Simpson was the main suspect of the crime. On June 16th, 1994 the LAPD pressed murder charges against him and placed a warrant for his arrest
However, there are side effects when taking this medication, such as: inflamed gums, acne, diarrhoea, increase in weight and abdominal pain. But this can be prevented by the doctor finding the best dosage to compact these side effects. Yet, there are other long term risks that arise from having a kidney transplant. Diabetes is one of them for the reason that people Feel a lot better and decide to eat more, causing a substantial increase in weight. Even certain kinds of immune-suppressants can develop the chance of diabetes. Another long term risk is high blood pressure because a lot of people who need this transplant already have an increased risk of obtaining high blood pressure and it does not help when taking immune-suppressants as it can make it worse. The other long term risk is cancer because the enduring use of immune-suppressants can increase different types of this condition, for example lymphoma (tumour in lymph node), skin cancer and “Kaposi’s sarcoma – a type of cancer that can affect both skin and internal organs” as mentioned by (NHS, 2014).
Some of the factors that patients do not adhere to when their healthcare provider tells them too is due to patients being too busy. Often times life is very busy as we all know this but forgetting to take of yourself can have detrimental effects to your health. Some people think they can get better on their own without the help of a doctor so they feel like they will be fine or able to handle any health complication on their own. Another reason is that often people do not understand or they forget what the doctor is telling them about their prescribed treatment regimens and other patients decide to simply not follow it. As stated in the article by Sklar, Min Sen Oh & & Chuen Li, 2008 “Poor communication with healthcare providers was also likely to cause a negative effect on patient’s compliance (Bartlett et al 1984; Apter et al 1998)”. Miscommunication between a doctor and patient is at the root of most adherence problems. Often times patients leave their doctors office not knowing or having the slightest clue to what they should be doing. Instead of asking for help or clarity they just leave. Communication needs to be clear and effective for both the patient and the doctor. Non-adherence is wide spread when it comes to patients not adhering to what professionals tell them. Many patients will have significant risks because they forget,
"We're advocates for the patient. We have no conflict of interest with the drug companies, and we're not against generics," said Dr. Flavio Vincenti, president of the American Society of Transplantation. Last September, Vincenti's medical specialist group filed a citizens' petition calling for more stringent FDA review of generic immunosuppressant drugs for transplant patients. And it has backed a wide range of state laws that would constrain generic substitution.
" When I missed my dose, I did not have any withdrawals. I felt fine, Charlene.....I am just tired of having to come there everyday and its affecting my work schedule. I tried to call you and I know you were busy as you just returned from vacation.....I have a lot going on. I do not need doctor to tell me that I cannot go down because I am still using." This writer explained to the patient as to why the doctor made the comment due to past consultation over the summer. The patient is aware of the clinic's concern, but does not feel to continue due to the risk
Adherence generally describes the degree to which the patient correctly follows medical advice. Immunosuppressive non-adherence is the most studied area and most prevalent compared with non-adherence to other drugs. Typically, a healthcare provider can expect 23 non-adherent patients out of 100 transplant patients (Dew et al. 2007). Everyday, on an average, a transplant patient takes 11 pills that include immunosuppressive and other supportive drugs (Ponticelli et al. 2010). This a huge burden on a patient and missing doses can lead to many outcomes such as graft impairment, increased mortality and increased healthcare cost (Dew et al.
New onset diabetes after transplant (NODAT) is an important complication after transplantation that increases risk for poor patient and graft outcomes. Recent studies in children identified older age, extremes of body mass index (BMI), and corticosteroid use at discharge as risk factors for NODAT. However, these studies were conducted in a national sample which underrated certain patient groups like deceased donor transplants and African American recipients. The purpose of this study was to determine the association between acute rejection (a surrogate for increased corticosteroid exposure) and NODAT in a pediatric kidney transplant program. A retrospective chart review was performed on a cohort of 121 consecutive pediatric kidney
The provision of written medication information given to the patient helps significantly in cases of medication non compliance (McGraw & Drennan 2004). This is because it aids in memory retention and presents patients with access to a reliable source of concise medication information, particularly if the patient needs to be reminded of certain aspects (Gorgos 2006). These written medication information sheets need to be provided in the patients primary, dominant language because it reduces the difficulty and limits barriers to patient understanding (Gorgos 2006).This is important because this intervention aims to increase a patient’s understanding of their medications, and when a patient feels more competent with the use of their medications, reduced
Three patients recovered without modification of the protocol, while two patients failed to recover. Two patients recovered after the addition of thymoglobulin and plasma exchange, and one of them required additional steroid therapy 103. Each of these protocols is currently being modified in order to achieve improved results. This study confirmed the safety of the approach and although this protocol found limited success, it underscores the motivation to identify a better line of treatment for kidney transplant recipients.
There are thousands of kidney transplants done a year in the United States. However, after transplantation, the patient’s immune system will see the new kidney as an invader and attack it. To counteract this phenomenon, physicians prescribe immunosuppressants. Although immunosuppressants are necessary for the body to accept the new kidney, many side effects of these medications have been established, with many of these effects being specifically harmful to the kidneys, so the question that needs to be answered is how do we ensure the long-term survival of renal transplant patients? Dr. Bai’s research focused specifically on the immunosuppressant Cyclosporine A (CsA). In the body, CsA’s specific target is Calcineurin A (CnA), which plays an