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Statement of Purpose The purpose of this study is to test an intervention of dose adjustment on medication adherence and side effects of non-adherence in kidney transplant patients, specifically, to compare switching from a twice-daily dose of tacrolimus to a once-daily dose of tacrolimus, to improve medication adherence and prevent or reduce transplant rejection and graft loss in kidney transplant recipients. Clinicians play a vital role in helping patients make treatment decisions that are most beneficial for their health and values, making adjustments of medication dosages and educating patients on benefits, side effects, and adverse outcomes of these choices. Research Question A research question was developed to assess effects of …show more content…

Among kidney transplant recipients risk factors for non-adherence are health illiteracy, forgetfulness, frequency of dosing, medication changes, and complex medication regimens. Within overall transplant patients, non-adherence to immunosuppression therapy contributes to 20 percent of late acute rejection episodes and 16 percent of graft losses (Lieber, Helcer & Shemesh, 2014). In clinical practice, there is a absence of a systemic approach in identifying and treating non-adherence (Lieber, Helcer & Shemesh, 2014). Evidence is lacking in non-adherence studies that demonstrates a relationship between perceptions and medication adherence (Massey et al., 2015). A major limitation of these studies is that a cross-sectional design impedes causal relationships and investigation of changes over time (Massey et al., 2015). A better understanding of patient behaviors toward their immunosuppression medication, reasons for taking tacrolimus and any action that is reducing their pill intake is an important step for future actions proposed to improve adherence and transplant outcomes. According to Massey et al. (2015), some illness perceptions include the perceived cause or causes of the illness, timeline (acute, chronic or cyclical), identity or label that it is given, personal control over outcomes, effectiveness of treatment to control outcomes,

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