Paracetamol For Fight Fever And Pain

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Although paracetamol was used clinically for the first time by Joseph von Mering in 1883 and it has been commercialized since 1953, its mechanism has not been discovered yet. However, paracetamol is the most used drug to fight fever and pain currently due to its antipyretic and analgesic properties. The aim of the experiment is the production of paracetamol by formation of an amide bound between the amine group of p-aminophenol and the carbonyl group of acetic anhydride. Furthermore, drugs used in humans must pass Quality Control (QC) and Quality Assurance (QA) in order to ensure the purity of the substance. In the current experiment, methods such as melting point range analysis, Thin Layer Chromatography (TLC) and NMR spectrometry will be used in order to assess the purity level of the synthetized paracetamol.

Experimental Procedure
In part 1, around 1.5 g of p-aminophenol was weighted and added into 100 mL Erlenmeyer flask and then placed on a steam bath. While the flask was being heated, 1 mL of water: ethanol (1:1) was added continuously until p-aminophenol was dissolved. The flask was let to cool down at room temperature until crystals started to form, then the flask was placed into an ice bath. The compound was filtered using a vacuum filtration apparatus and a Buchner funnel until crystals were dried. Formed compound was weighted and 10 g was kept for later use. Recrystallised p-aminophenol was placed into a 100 mL Erlenmeyer flask and 9 mL of water
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