Paracetamol Solubility Research Paper

The goal of the solubility experiment is to determine weather a substance is soluble or insoluble using various techniques. In part A of the experiment the solubility of different substances in different solvents will be investigated. To achieve the goal of part a 40 mg of benzophenone will be placed into test tubes. Each test tube will contain a different solvent and one will serve as a control. A spatula will be used to stir the contents in the test tube, once this step is complete it will be determined if the solid is soluble, insoluble, or partially soluble. Like part A, part B will also test the solubility, however the solubility of different alcohols will be tested to do this 1 mL of water or hexane will be added to each test tube

Benzophenone was soluble in methyl alcohol whiles biphenyl was partially soluble. Benzophenone and biphenyl are both nonpolar molecules. Methanol is intermediately polar, allowing both nonpolar molecules to be dissolved as it is not too polar or nonpolar. However, biphenyl is less polar than benzophenone. Since methyl alcohol is somewhat polar, the more polar benzophenone is more soluble in methyl alcohol than biphenyl. Also, benzophenone can make hydrogen bonds. Thus, benzophenone is more soluble in methyl alcohol than

Sucrose is insoluble in the organic solvent dichloromethane (CH2 Cl2). Aspirin, acetanilide, and phenacetin are soluble in dichloromethane but relatively soluble in water. Aspirin reacts with bases such as sodium bicarbonate to form a salt, sodium acetylsalicylate, which is insoluble in water. Acetanilide and phenacetin are not converted into salts by sodium bicarbonate.

Panadol 6 will dissolve faster than any other panadol and all type of panadol will have increase solubility in acidic conditions

Which brand of painkilling medicine dissolves the fastest and does flavor, coating, and color of the pill affect the dissolution time? If several different pain neutralizing pills are placed in stomach acid and timed in order to find out which pill dissolves first, then the most effective pill will be the first to dissolve. In order to test this, eight different types of pain neutralizing medicine were put into simulated stomach acid and timed. Normal strength, liquid gel capsules, and children's flavored pills were all tested. In order to accurately simulate stomach acid, vinegar, which has the same pH levels of stomach acid, was heated to thirty seven degrees Celsius and stirred constantly and evenly. The pills tested were Advil, Children's

Acetaminophen is a worldwide known drug used for aches and pains, but that is all that is thought of when the name is said. Because it is an over the counter medicine, nobody thinks about the effects it can have on you. In fact most people don't even read the warning label. In this paper, it will discuss all of the things nobody even bothers themself to look into. Such as common name/s, what it should be prescribed for, uses, side effects, warnings, drug interactions, and the chemical composition for it. This essay attempts to prove that Acetaminophen is more than just a benign remedy for discomfort.

The purpose of using solubility analysis on an unknown is to narrow the possible unknowns given based on the solubility analysis. Acetone was a control for ketone and was soluble in water. Hexanal was a control for an aldehyde and was insoluble in water due to intermolecular forces, such as an increased amount of hydrophobic area rather than hydrophilic area. As a result, by identifying the solubility of the

Albuterol also known as Salbutamol is a common medication used to treat asthma and similar respiratory ailments.[1] Albuterol is a bronchodilator and works to open the airways of the lungs. Albuterol can be taken intravenously or orally. The preferred method of this substance is orally, which in itself have various ways of being administered. One way is by inhalation, either from a vapor mist in the form of an inhaler and a nebulizer or, as a powder like Advair. In addition to inhalation, albuterol can be ingested as syrup or a tablet. Because of it varying forms Albuterol is can easily meet the need of the patient, making it a popular medication to treat asthma, emphazma, bronchitis and other airway constricting disorders.

In the extraction of certain compounds, solubility plays an important factor in how the procedure is performed. The identification of which solvent is best for the substance is crucial. The relation of polarity between the solute and solvent is determined at a molecular level. The relationship between the solvent and solute needed shared similar characteristics. Polar solutes are dissolved in polar solvents while nonpolar solutes are dissolved in nonpolar solvents. From a chemical level, molecules are attracted to other similar molecules closest to their properties. Polar molecules are only attracted to polar molecules in both the solute and the solvent, and the same goes for nonpolar molecules. This explanation

Proposed mode of action for RIS (benzisoxazole derivative) is blocking of 5-HT2A and dopamine D2 receptors. Despite of its potential, RIS is reported to have higher log P value along with poor water solubility and is classified as biopharmaceutical classification system (BCS) class II drug [6]. This poor water solubility leads to limited oral bioavailability through gastrointestinal tract as well as by parenteral route and limits the use of aforementioned drug candidate [4]. Various solubility enhancement techniques can be used to enhance apparent solubility of BCS class II drugs such as salt formation, solid state modification, use of co-solvents, hydro-trophy, complexation with cyclodextrins size reduction etc. Researchers have reported solid dispersion [7], self-nano-emulsifying powder [8] and co-solvent [9] approach for enhancement of RIS water solubility. Use of sodium lauryl sulphate (SLS) in marketed formulation (Risperdal®) of drug presents the probability of solubility enhancement with the use of surfactant [10]. All these approaches have their own advantages and limitations like toxicity issues associated with use of co-solvents [11] (generally water miscible organic solvents) and surfactants beyond a particular level

The hypothesis that the denser the solvent is, more solute will dissolve in a quicker time period was correct. These results occurred because sugar has polar energy, which makes it easy to dissolve in water which is also polar. Vegetable oil is nonpolar, so these two substances do not mix. Rubbing alcohol is somewhat polar although it is mostly non-polar, which leads to some sugar dissolving but not all. A possible source of experimental error could be the mixing of two solvents. When the water was poured into the beaker, some oil was still in the beaker, causing the two to mix, making less sugar dissolve. However, the amount of solvent mixed was minimal, so hhit had a small effect on the results in the data. If this experiment were to be made again, then three different beakers and graduated cylinders could be used to measure out the solvents separately so two substances will not

absorption of acetaminophen has a pKa of 9.5 and in the alkaline medium of the duodenum

• So if the pH of a drug solution has to be adjusted to improve solubility and the resultant pH leads to instability then a way out of this tricky problem is to introduce a water miscible solvent into the product. It will increase stability by:

Aspartame is soluble in water in small amounts at a time (However if people were going to use solute Aspartame to use in a beverage, a small amount would be used since it is 200x sweeter than sugar.)

As mentioned in the discussion, olive oil, vegetable oil, crisco, and lard were soluble in nonpolar solvents and insoluble in polar solvents. This is due to the chemical composition of polar and nonpolar substances which results from the molecular shape as well as properties of dissolving solutes in solution. Polar substances are hydrophilic and contain polar Van Der Waals interactions (intermolecular forces) such as dipole-dipole forces, ion-dipole forces, and hydrogen bonding. Nonpolar substances are hydrophobic and contain non-polar Van Der Waals interactions. ‘Like dissolve like’ is the reason only polar solutes dissolve in polar solvents and why nonpolar solutes dissolve in nonpolar solvents. Molecules with similar polarity have similar intermolecular forces and therefore, can interact with each, or in this case dissolve9. Additionally, the solubility of a compound is determined by the length of the hydrocarbon chain. Long hydrocarbon chains such as the one found in oleic acid makes a compound more insoluble10. Therefore, since the lipids used in this experiment were hydrophobic substances and each lipid has long hydrocarbon chains, the results were consistent with the scientific literature and principles.