Parasites: T. Cruzi

1979 WordsFeb 24, 20188 Pages
Parasites are organisms found in almost every niche and some species have evolved to the point of developing characteristics for intracellular survival, which is the case of the parasite Trypanosoma cruzi that causes Chagas disease. T. cruzi is transmitted to the vertebrate host through the feces of triatomine bugs in which the infective forms, metacyclic trypomastigotes, are inoculated after the insect bite. The establishment of T. cruzi infection depends on a number of factors that begins with the invasion of host cells, which mobilizes various effector mechanisms of the immune system, such as the activation of factors related to innate immunity and acquired immunity. This research paper aims to answer what are the types of immune response used by the infected host during the developmental stages of the parasite, as well as what are the possible evasion mechanisms used by the T. cruzi that allows its survival in a hostile environment created by the response of the host immune system. American trypanosomiasis or Chagas disease was discovered by the Brazilian physician Carlos R. J. Chagas in 1909. Chagas disease is caused by the flagellated protozoan Trypanosoma cruzi, which is mostly transmitted during a meal blood of blood‑sucking triatomine insects (kissing bugs). Triatomine insects have wide variety of hosts such as skunks, dogs, cats, armadillos, goats, sheep, which serve as a reservoir of the disease (Nouvellet et al. 2013). Inside of the triatomine insects occurs the
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