Parkinson’s Associated Dementia

Dementia with Lewy bodies (DLB) is a form of dementia which shares characteristics with both Alzheimer’s and Parkinson’s disease. It accounts for around 10% of all cases of dementia in older people and tends to be under-diagnosed. 
Named after the doctor who first identified them in 1912, Lewy bodies are tiny, spherical protein deposits found in nerve cells. Their presence in the brain disrupts the brain’s normal functioning, interrupting the action of important chemical messengers. Lewy bodies are also found in the brains of people with Parkinson’s disease, a progressive neurological disease that affects movement. 
Dementia with Lewy bodies is

Parkinson disease (PD) is one of the most common neurologic disorders. and it affects approximately 1% of individuals older than 60 years old. Parkinson’s disease is a condition that progresses slowly by treatment. In addition, loss of pigmented dopaminergic neurons of the substantianigra pars compacta and the presence of Lewy bodies and Lewyneurites are the two major neuropathologic findings in Parkinson disease (Hauser, 2016).

If you eat unhealthy, fatty foods your whole life, you have a higher risk of developing diabetes, cardiovascular disease, or arteriosclerosis. If you have unprotected sex, you may contract a sexually transmitted disease, such as syphilis, gonorrhea, or HIV/AIDS. But, Parkinson’s doesn’t racially discriminate, nor does it care if someone is wealthy, poor, educated, non-educated, male or female. Anyone can develop Parkinson’s disease. The disease begins in the brain, our most intricate, delicate organ, whose complexity is still not entirely understood, even with today’s technology and experts. The brain intrigues me. I find myself curious about brain

Parkinson’s disease is a “neurodegenerative disorder of the basal nuclei due to insufficient secretion of the neurotransmitter dopamine” (Marieb & Hoehn, 2013, p. G-17). The cause of Parkinson’s disease is unknown, but many factors play a role in the development of Parkinson’s disease. One factor that has been found in an individual who has Parkinson’s disease causes over activity of targeted dopamine-deprived basal nuclei. This over activity is caused by the breakdown of neurons that release dopamine in the substantia nigra (Marieb & Hoehn, 2013). Another factor that is present in a person who has Parkinson’s disease, is the presence of lewy bodies in the brain stem ("What is lbd?," 2014). Lewy bodies are unusual

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most widespread age-related neurodegenerative diseases. Both diseases impact a considerable number of people, where AD occurs in around 10 percent of the population greater than the age of 65 while PD occurs in roughly 1 percent of the population above the age of 65. AD is considered to be the most widespread cause of dementia, characterised by the progressive memory and cognitive deficits which impair ones day to day activities. The pathological hallmark of AD comprises of extracellular accumulation of senile plaques consisting of mainly amyloid-beta (Aβ) peptides, along with neurofibrillary tangles which are composed of the phosphorylated tau protein, located in the hippocampus and cortex. Conversely, PD is considered to be the most widespread movement disorder that is characterised by symptoms such as rigidity slow movements, resting tremor and other instabilities. The extreme loss of dopaminergic neurones in the substantia nigra is what defines PD, as the loss of this nerve cell can be linked to Lewy bodies containing aggregates of a soluble protein called α-synuclein.

Dementia with Lewy bodies (DLB), when cognitive symptoms appear within a year of movement problems, is a complex and challenging neurodegenerative disorder. (Pervin, Edwards & Lippa, 2016). It is complex because the DLB pathology and its impact on certain brain regions are unclear. The pathology includes Lewy bodies, senile plaques and neurofibrillary tangles. It is challenging because its many core features make it difficult for individuals to perform activities of daily living. The core clinical features comprise of declining and fluctuating cognition, behavioural and psychotic behaviours and spontaneous signs of parkinsonism.

Parkinson’s disease, a type of dementia also known as idiopathic or primary parkinsonism, paralysis agitans, or hypokinetic rigid syndrome/HRS, is on the rise in the U.S. Each year there are over 60,000 new cases in the U.S. alone. With the average person diagnosed with Parkinson’s disease over the age of 65 and America’s rapidly growing elderly population, awareness and concern are becoming significant points of interest for many healthcare professionals.

While aging does not harm a person Its effects can devastate families, children, and acquaintances. 3 of the most well-known effects of Aging Are Parkinson's, alzheimers, and dementia. Well both diseases can take a toll on a person, they each take a different part of a person. Parkinson's effects the inner workings of the brain causing tremors And cannot be cured. Dementia is a disease that eats away at a senior citizens memory, many elderly patients have died due to the fact they forgot how to swallow and choke on their own saliva. Dementia is also linked to forgetfulness in senior citizens because it does interfere with daily living and functionality in their daily lives. Well all three diseases are very different they all do

Parkinson’s disease is a progressive disorder of the central Nervous system and affects both motor and nonmotor functions. parkinson 's is caused by a chemical imbalance within the brain. The brain produces a neurotransmitter called dopamine in the basal ganglia, which is structures linked to the thalamus in the base of the brain. If the Dopamine, Basal ganglia and Thalamus does not function properly then causes major damage,. A person having less and less dopamine, the individual has less and less ability to regulate their movements, body and emotions. Although there is no current cure available for Parkinson’s disease, the debilitating conditions can be lessoned through education, therapy, and a variety of treatments to improve their quality of life on the National Parkinson Foundation website.

Although the etiology of idiopathic Parkinson's disease (PD) is unknown, it is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) of ventral midbrain region [9]; [1]. Its prevalence is associated with age. Approximately 1% of the population is affected at 65–70 years of age, which increases to 4–5% in 85-year-olds [2]. Various epidemiological studies and pathological analyses have demonstrated that mean age of onset in sporadic PD, which accounts for about 95% of cases of Parkinsonism is 70 years [7]; [3]. Familial form of Parkinson’s disease is linked to genetic mutations and has prevalence rate of 4%. Familial Parkinson’s disease patients develop early-onset disease before the age of 50

Affecting an estimated 4 million people worldwide (NIH), Parkinson’s is one of the less common nervous system disorders. Despite its rarity, Parkinson’s is largely researched because there is no cure and few effective treatments. It also has a big impact on quality of life for those afflicted. This disease usually shows up after age 40 and occurs when the brain cells that are responsible for motor skills die. Symptoms include tremors, inability to move, and impaired cognitive function, all of which worsen over time. Because this is a condition that affects the brain, if an effective treatment can be established, treatments for other more common conditions such as Alzheimer’s may soon follow. This makes it a critical topic for today’s doctors and scientists.

Parkinson 's disease, like Alzheimer’s is more common in later ages but is affecting youth and young adults. It is the second most common neurological degenerative disorder, and has been found to affect 6 million people worldwide. The disease is a progressive motor syndrome that impairs the heart, muscles, and central nervous system. Intracellular inclusions, Lewy bodies, and dopaminergic neuronal loss effect Parkinson’s disease. In 5–10% of Parkinson’s cases, they are familial and transmitted in either an autosomal-dominant or an autosomal-recessive fashion. (Gandhi, 2010)

The question may arise, what exactly is Parkinson’s disease? Parkinson’s disease is a progressive degenerative neurological disorder, which means that it gets worse over time. PD is more common with increasing age affecting 1% of the population above 55, with 4-10% of cases having early onset before the age of 40 (XXXX). The average age of onset ranges between 58-62 years old and is more common in men than women. The disease itself is defined by the presence of lewy bodies in neurons and a loss of dopamine. Degenerative changes to the basal ganglia affect the nerve cells in the substantia niagra that produce dopamine. This results in a decrease in the production of dopamine that is getting to the brain. Dopamine is a neurotransmitter involved with regulating movement making early signs of PD primarily motor impairments and progression of this disease can range from

Parkinson’s disease is affected by the degeneration of dopaminergic neurons which is responsible to produce dopamine. Dopaminergic neurons have their cell bodies in substantia nigra pars compacta (SNpc) in basal ganglia (O’Sullivan and Schmitz, 2007). Basal ganglia are a collection of interconnected gray matter nuclear masses deep within the brain”. These gray matter masses are caudate, putamen, globus pallidus, subthalamic nucleus and the substantia nigra. Basal ganglia receive its input through striatum (O’Sullivan and Schmitz, 2007).

Parkinson disease (PD) is a progressive neurodegenerative disorder characterized mainly by physical and psychological disabilities. This disorder was named after James Parkinson, an English physician who first described it as shaking palsy in 1817 (Goetz, Factr, and Weiner, 2002). Jean- Martin Charcot, who was a French neurologist, then progressed and further refined the description of the disease and identified other clinical features of PD (Goetz, Factr, and Weiner, 2002). PD involves the loss of cells that produce the neurotransmitter dopamine in a part of the brain stem called the substansia nigra, which results in several signs and symptoms (Byrd, Marks, and Starr, 2000). It is manifested clinically by tremor,