Parkinson's Disease: A Narrative Analysis

Neurology is one of the most unexplored fields in medicine; however, more recently there has been a spike in the amount of research being done in this specialty. This is because people are becoming more interested in neuroscience, including myself. I attended a pre-medical vocational high school, which exposed me to a greater amount of knowledge pertaining to the basics of anatomy and physiology, along with hands-on opportunities in a medical setting. It was here where I realized that I wanted to pursue a career in medicine; however, due to the fact medical field is very broad, I had no set specialty. This changed when I was exposed to the cruel manifestations of Parkinson’s Disease. During, sophomore year of high school, my grandfather passed away due to complications of Parkinson’s Disease. The way that a neurodegenerative disease was able to overtake a person in the manner that it did was shocking, and while it brought me great grief initially, it later intrigued me. I took up an interest in neuroscience and began to do my own research which culminated in various projects and applications throughout the remainder of my time in high school. These experiences have culminated in my decision to work toward a Cell Biology and

As I stepped into the mud room to take off my bright pink rainboots, I knew something was not normal. As I glided onto the sleek wood floors to grab a crunchy after-school snack, I hear my mom descend down the carpeted stairs slowly, becoming aware that this will not be a normal “how was your day at school” conversation. I raced to the cabinet to grab my fix of Goldfish and I sat down on the floor to get a little snuggle time with my dog before my world was turned upside-down.

Parkinson disease (PD) is one of the most common neurologic disorders. and it affects approximately 1% of individuals older than 60 years old. Parkinson’s disease is a condition that progresses slowly by treatment. In addition, loss of pigmented dopaminergic neurons of the substantianigra pars compacta and the presence of Lewy bodies and Lewyneurites are the two major neuropathologic findings in Parkinson disease (Hauser, 2016).

By the time someone shows signs and symptoms of Parkinson 's, Dopamine production in the brain has been reduced by 60 to 80% and is fairly advanced. This results in the most recognizable sign of Parkinson 's disease, the resting tremor of the hand or hands. During deliberate movement, the resting tremor goes away, at first. At rest, the tremor will become exacerbated,

Cancer and Parkinson’s disease are similar in many ways. The symptoms of the patients can be quite indistinguishable. Both damage the body’s cells. Also, symptoms worsen as time passes. Parkinson’s and Cancer both cause damage to the brain. The video titled, “Parkinson’s disease- a journey through a brain” informs viewers of the nasty symptoms of Parkinson’s disease. “The disease damages the brain, creating tremors in some people, muscle stiffness, an inability to move, memory damage, anxiety and depression” (AP). Cancer and Parkinson’s can give off unbearable physical pains. Christopher Hitchens describes his personal experience with Cancer in the “Topic of Cancer”. “I have more than once in my time woken

I whisper to myself as I approach the patient. I need to notice every detail. I must not miss a single word or a single movement. Each detail is a clue and each clue is imperative to solve the case and find the diagnosis. I am Sherlock Holmes and this is my mystery to solve. I take a deep breath.

J.N., a 65-year-old Caucasian female with a history of anxiety and depression, presents for diagnostic testing at Saint Mary Medical Center in Hobart, Indiana to confirm or deny a diagnosis of Parkinson’s Disease, after presenting with recent onset of upper extremity tremor affecting both sides and facial masking. Patient history also includes bradykinesia, restlessness, fatigue, muscle weakness, and poor balance and coordination, all of which are common in a diagnosis of Parkinson’s Disease. J.N. was referred to the Neurology Department of Saint Mary Medical Center after a routine appointment with her Cardiologist, who noted the recent onset of additional signs and symptoms. J.N. is my mother and my inspiration for this assignment.

In 1991 Fox was diagnosed with early-onset Parkinson’s disease (PD), he did not reveal his diagnosis to the public until 1998. (Michael J. Fox Foundation) Parkinson’s disease is complex neuro-degenerative disease and is considered idiopathic with only a small percentage of cases considered genetically linked. Diagnosis is based solely on a patient’s history, age, and clinical manifestations. Early-onset Parkinson’s varies from idiopathic Parkinson’s in that there is a mutation in the Parkin gene.

Parkinson’s disease is a “neurodegenerative disorder of the basal nuclei due to insufficient secretion of the neurotransmitter dopamine” (Marieb & Hoehn, 2013, p. G-17). The cause of Parkinson’s disease is unknown, but many factors play a role in the development of Parkinson’s disease. One factor that has been found in an individual who has Parkinson’s disease causes over activity of targeted dopamine-deprived basal nuclei. This over activity is caused by the breakdown of neurons that release dopamine in the substantia nigra (Marieb & Hoehn, 2013). Another factor that is present in a person who has Parkinson’s disease, is the presence of lewy bodies in the brain stem ("What is lbd?," 2014). Lewy bodies are unusual

Parkinson disease (PD), also referred to as Parkinson’s disease and paralysis agitans, is a progressive neurodegenerative disease that is the third most common neurologic disorder of older adults. It is a debilitating disease affecting motor ability and is characterized by four cardinal symptoms: tremor rigidity, bradykinesia or kinesis (slow movement/no movement), and postural instability. Most people have primary, or idiopathic, disease. A few patients have secondary parkinsonian symptoms from conditions such as brain tumors and certain anti-psychotic drugs.

When people hear the words Parkinson’s disease they think, “Isn’t that what Michael J. Fox has?” For those who are asking, “Who is Michael J. Fox?” He was the character Marty McFly in the “Back to the Future” movie and played on many TV shows. After being diagnosed with Parkinson’s disease, he set up an organization to research Parkinsonism. What the Michael J. Fox Foundation found was that 40 percent of the people living with Parkinson’s disease experience dystonia as an early symptom or a complication of treatment. This is the only blurb you see on the website about dystonia. In fact, it is so much like the other disorders out there that many people have never heard of it. The purpose of this paper is to inform

Parkinson’s Disease is a long-term progressive neurodegenerative disease consisting of motor system impairment, neuropsychiatric, and nonmotor features. The disease is characterized by the following key clinical features: bradykinesia, resting tremor, postural instability, and rigidity. These symptoms are due to the diminishing of dopamine in the nigrostriatal pathway and substantia nigra, which causes inhibition of the thalamus decreasing excitatory input to the motor cortex.1 Along with the key manifestations an individual with Parkinson’s Disease will experience problems associated with the disease or the antiparkinson medications. These co-occurring problems are hallucinations, dementia, daytime sleepiness, fatigue, depression, and pyschosis.2 Psychosis is a common problem in Parkinson’s Disease, and is characterized by paranoid delusions and hallucinations that are visual in nature.2 Risk factors for psychosis consists of advancing age, dementia, sleep disorders, and high doses of antiparkinson drugs.1

Parkinson’s Disease is known as one of the most common progressive and chronic neurodegenerative disorders. It belongs to a group of conditions known as movement disorders. Parkinson disease is a component of hypokinetic disorder because it causes a decreased in bodily movement. It affects people who are usually over the age of 50. It can impair an individual motor as well as non-motor function. Some of the primary symptoms of Parkinson’s disease are characterized by tremors or trembling in hands, legs and arms. In early symptoms the tremor can be unilateral, appearing in one side of body but progression in the disease can cause it to spread to both sides; rigidity or a resistant to movement affects most people with Parkinson’s disease,

Negative and cognitive symptoms are seen within many neurological disorders. These disorders typically are related to some type of brain damage to the frontal lobes. Positive symptoms are slightly different, they seem to involve excessive activity in a few neural circuits that include dopamine as a neurotransmitter, while negative and cognitive symptoms seem to be caused by or related to degenerative or developmental processes, of which impair normal functions of some of the regions within the brain.

Parkinson disease (PD) is a progressive neurodegenerative disorder characterized mainly by physical and psychological disabilities. This disorder was named after James Parkinson, an English physician who first described it as shaking palsy in 1817 (Goetz, Factr, and Weiner, 2002). Jean- Martin Charcot, who was a French neurologist, then progressed and further refined the description of the disease and identified other clinical features of PD (Goetz, Factr, and Weiner, 2002). PD involves the loss of cells that produce the neurotransmitter dopamine in a part of the brain stem called the substansia nigra, which results in several signs and symptoms (Byrd, Marks, and Starr, 2000). It is manifested clinically by tremor,