Parkinson disease (PD), also referred to as Parkinson’s disease and paralysis agitans, is a progressive neurodegenerative disease that is the third most common neurologic disorder of older adults. It is a debilitating disease affecting motor ability and is characterized by four cardinal symptoms: tremor rigidity, bradykinesia or kinesis (slow movement/no movement), and postural instability. Most people have primary, or idiopathic, disease. A few patients have secondary parkinsonian symptoms from conditions such as brain tumors and certain anti-psychotic drugs.
Parkinson’s disease is a common disease facing many older people across the world. It affects the central nervous system and it impairs cognitive processes, motor skills and other functions. This disease mostly affects the older generation and it manifests itself with symptoms which include rigidity, tremor, postural instability, slowness in movement and others. Other symptoms include sleep difficulties, sensory and autonomic dysfunction. Parkinson’s disease has a high prevalence rate among older people with approximately 500,000 people suffering from the disease in the United States. In addition, there are approximately 1 million people who suffer from the disease but they have not been diagnosed yet (Oxtoby et. al.,
Parkinson disease (PD) is a progressive neurodegenerative disorder characterized mainly by physical and psychological disabilities. This disorder was named after James Parkinson, an English physician who first described it as shaking palsy in 1817 (Goetz, Factr, and Weiner, 2002). Jean- Martin Charcot, who was a French neurologist, then progressed and further refined the description of the disease and identified other clinical features of PD (Goetz, Factr, and Weiner, 2002). PD involves the loss of cells that produce the neurotransmitter dopamine in a part of the brain stem called the substansia nigra, which results in several signs and symptoms (Byrd, Marks, and Starr, 2000). It is manifested clinically by tremor,
James Parkinson first discovered Parkinson's Disease in 1817. Parkinson's Disease is a common neurologic disorder for the elderly. It is a disorder of the brain characterized by shaking and difficulty with walking, movement, and coordination. This disease is associated with damage to a part of the brain that controls muscle movement. Parkinson's Disease is a chronic illness that is still being extensively studied.
Parkinson’s disease, a type of dementia also known as idiopathic or primary parkinsonism, paralysis agitans, or hypokinetic rigid syndrome/HRS, is on the rise in the U.S. Each year there are over 60,000 new cases in the U.S. alone. With the average person diagnosed with Parkinson’s disease over the age of 65 and America’s rapidly growing elderly population, awareness and concern are becoming significant points of interest for many healthcare professionals.
Parkinson's disease is a progressive neurological disorder that slowly erodes an individual's ability to care for themselves. Parkinson's does not have a standard set of symptoms and each person's experience with Parkinson's is unique. What is common is that the disease affects the body's ability to control muscle movements. This may result in tremors, muscle rigidity, difficulty walking, and an inability to perform any task requiring fine motor skills. There is no known cure for Parkinson's disease, and its progressive nature ensures that it is highly debilitating.
Parkinson’s is a progressive neurodegenerative disease, primarily affecting voluntary, precise, and controlled movement. Parkinson’s occurs when cells in a part of the brain called the substantia nigra die off. These cells are responsible for producing dopamine. With less and less dopamine, a person has less and less ability to regulate their movements, body and emotions. The terms "familial Parkinson's disease" and "sporadic Parkinson's disease" are used to differentiate genetic from truly idiopathic forms of the disease.
Parkinson’s Disease is a long-term progressive neurodegenerative disease consisting of motor system impairment, neuropsychiatric, and nonmotor features. The disease is characterized by the following key clinical features: bradykinesia, resting tremor, postural instability, and rigidity. These symptoms are due to the diminishing of dopamine in the nigrostriatal pathway and substantia nigra, which causes inhibition of the thalamus decreasing excitatory input to the motor cortex.1 Along with the key manifestations an individual with Parkinson’s Disease will experience problems associated with the disease or the antiparkinson medications. These co-occurring problems are hallucinations, dementia, daytime sleepiness, fatigue, depression, and pyschosis.2 Psychosis is a common problem in Parkinson’s Disease, and is characterized by paranoid delusions and hallucinations that are visual in nature.2 Risk factors for psychosis consists of advancing age, dementia, sleep disorders, and high doses of antiparkinson drugs.1
From a clinical diagnosis standpoint, Parkinson’s is solely dependent on the physical symptoms that have been caused by the deficiency of dopamine because of the lack of neuron cells in the substantia nigra. Without high end laboratory maneuvers and MRIs of the brain, Parkinson’s can already be diagnosed just by observing the physicality of the patient. MRIs are usually used to rule out any other disorder that could also present the same symptoms as Parkinson’s. The primary symptoms in regards to this disease include akinesia, or loss or impairment of voluntary movements, bradykinesia, or slow movement, trembling in hands, arms head, and legs, stiffness in the trunk portion of the body and muscle flexors of the limbs, and unstable posture affecting balance. Parkinson’s is chronic and slow progressive and over time patients will begin to experience difficulty in normal tasks such as walking, talking, and other day to day activities (NINDS, 2013).
Each year more than 60,000 Americans are diagnosed with Parkinson’s disease (PDF, 2014). That sixty thousand does not include the many thousand cases that go undetected each year. Parkinson’s is a progressive disorder that occurs in the nervous system. This disease affects a person’s movement. Parkinson’s disease develops progressively. The most common first sign of Parkinson’s is slight shaking of a body part. In the initial phase of Parkinson’s a person will experience slurring of speech and an expressionless face (Mayo Clinic, 2014). With time, the symptoms of Parkinson’s exacerbate. This disease is most frequently seen in people over the age of 50 (PDF, 2014). Parkinson’s disease is generated by a great number of reasons.
One of the most commonly seen neurological disorders is Parkinson’s disease (PD). Named after the doctor who first identified the disease as “the shaking palsy” Dr James Parkinson (1755-1824), Parkinson’s disease affects over 1 million Americans today. On average around 60,000 Americans are diagnosed with Parkinson’s disease annually. This is an alarming number of new cases but what is even more startling is the fact that thousands of cases go undetected each year as well. PD is a clinical diagnosis with no definitive diagnostic test to identify the disease.
Although the etiology of idiopathic Parkinson's disease (PD) is unknown, it is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) of ventral midbrain region [9]; [1]. Its prevalence is associated with age. Approximately 1% of the population is affected at 65–70 years of age, which increases to 4–5% in 85-year-olds [2]. Various epidemiological studies and pathological analyses have demonstrated that mean age of onset in sporadic PD, which accounts for about 95% of cases of Parkinsonism is 70 years [7]; [3]. Familial form of Parkinson’s disease is linked to genetic mutations and has prevalence rate of 4%. Familial Parkinson’s disease patients develop early-onset disease before the age of 50
Definition: “Parkinson’s disease is a chronic, progressive disease of the nervous system characterized by the cardinal features of rigidity, bradykinesia, tremor, and postural instability” (O’Sullivan and Schmitz, 2007). The condition can develop between age group 60 and 80 years and symptoms mostly appear around 60 years of age (O’Sullivan and Schmitz, 2007).
The Basal Ganglia are structures in the subcortical part of the brain that help an individual plan and produce movements, form
Parkinson's is an idiopathic, multifactorial neurodegenerative disease that attacks neurotransmitters in the brain called dopamine. Dopamine is concentrated in a specific area of the brain called the substantia nigra. The neurotransmitter dopamine is a chemical that regulates muscle movement and emotion. Dopamine is responsible for relaying messages between the substantia nigra and other parts of the brain to control body movement. The death of these neurotransmitters affects the central nervous system. The most common symptoms are movement related, including shaking, rigidity, slowness of movement and difficulty with posture. Behavioral problems may arise as the disease progresses. Due to the loss of dopamine,