Partial Agonist Examples

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Partial agonist is a drug having same affinity for receptor as an agonist but less intrinsic activity than full agonist is called “PARTIAL AGONIST”. A partial agonist in presence of full agonist acts as antagonist, as it occupies the receptor and does not allow the full agonist to bind with receptor. Clinically, partial agonists can be used to activate receptors to give a desired submaximal response when inadequate amounts of the endogenous ligand are present, or they can reduce the overstimulation of receptors when excess amounts of the endogenous ligand are present. Some currently common drugs that have been classed as partial agonists at particular receptors include buspirone, aripiprazole, buprenorphine, and norclozapine. Examples of ligands
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