Pathogenesis : Disease And Its Effects On Renal Transplant Recipients Essay

The first organ donation was successfully performed in 1954 (Major). Since then, institutions have set up many regulations and processes that have saved many lives by allowing people to donate their organs, but government policies in the United States have set up laws that prevent individuals to make choices about their own bodies. The National Organ Transplant Act (NOTA) is a regulation that prevents those who prefer to profit from their donation. The purpose of the act was to, “prohibit the assignment of a monetary value to an organ for transplantation, thus preventing commercialization and ensuring some level of equity in access to organs” (Delmonico). “Punishment includes fines up to $50 000 and 5 years in prison” (Friedman). The only country that legalizes organs to be bought and sold is Iran. The Iranian government recognized the overwhelming increasing of resources needed for dialysis as more and more people were becoming ill, so the government decided to make it legal to pay citizens to have transplants mainly in the UK (Major). When a person is in need of an organ, doctors assess whether or not that person is eligible for a transplant (Bernard). Once they have been approved, the patient will be referred by the doctor to a transplant center where they evaluate the patient’s physical and mental health as well as the patient’s social support to clear the requirements for being considered a viable candidate for an organ transplant, and finding the right donor is all

Viruses are microscopic particles that invade and take over both eukaryotic and prokaryotic cells. They consist of two structures, which are the nucleic acid and capsid. The nucleic acid contains all genetic material in the form of DNA or RNA, and is enclosed in the capsid, which is the protein coating that helps the virus attach to and penetrate the host cell. In some cases, certain viruses have a membrane surrounding the capsid, called an envelope. This structure allows viruses to become more stealthy and protected. There are two cycles in which a virus can go into: lytic and lysogenic. The lytic cycle consists of the virus attaching to a cell, injecting its DNA, and creating more viruses, which proceed to destroy the host. On the other hand, the lysogenic cycle includes the virus attaching to the cell, injecting its DNA, which combines with the cell’s DNA in order for it to become provirus. Then, the provirus DNA may eventually switch to the lytic cycle and destroy the host.

Acute renal failure condition is diagnosed and retitled as acute kidney injury. The purpose of the change of terminology was to encompass the full spectrum of the clinical manifestations associated with the syndrome. This includes a range from a small decline in kidney function to a severe impairment. Furthermore, the acute condition is characterized by a rapid loss of kidney function. In addition, associated manifestation(s) may be displayed as a rise in serum creatinine or a reduction in urine output. As a result of increase of serum creatinine or decline in urine output may developed and aggress to the clinical manifestation azotemia.

The factors that lead to the development of KS is a weak immune system and inherited hhv-8

A weakened immune system can reactivate the BK virus and cause an infection. This can result from many conditions, including:

The body responds differently to an infection, depending on whether it is a virus or a bacterial infection. Generally, viruses are considered to be more dangerous, but aside from generalities, there are also pathophysiological differences in the ways in which both viruses and bacteria (invasive organisms) infect human beings (hosts). When a virus is the agent that is infecting the host, the goal of the virus is to invade on a cellular level and replicate itself. “Once inside, the cells of the immune system cannot ‘see’ the virus and therefore do not know that the host cell is infected. To overcome this, cells employ a system that allows them to show other cells what is inside them” (Immune, 2015). The virus then uses the cell in order to make proteins and replicate itself, further compromising the immune system. The immune

Acute renal failure, recently being called Acute Kidney injury (AKI), according to Susan Dirkes (2011), “the classification criteria for AKI include three grades of severity: risk of acute renal failure, injury to the kidney and failure of renal function.” (p.37).

Ms. S.M. was a patient admitted for the management of renal failure. During morning rounds, we noticed her potassium levels to be elevated. She was asymptomatic and her EKG did not show any abnormal changes. As a team, we coordinated with each other and successfully managed her potassium levels. The hours spent to manage this patient helped me to understand the importance of clear communication and the dynamics of team work in a hospital setting. Though we managed her hyperkalemia, the patient was still facing an uncertain prognosis with her kidney disease. Her family members were worried about providing financial support for her care, which is a major problem in India. It made me wonder if there was anything more we could do for her. However, along with providing clinical care, establishing a relationship with her and her son gave me a sense of satisfaction. It made me realize the potential of developing long term relations with my patients in this field.

Herpesviruses may cause direct cytopathic effects on certain cells (fibroblasts, keratinocytes, endothelial cells, inflammatory cells such as polymorphonuclear leukocytes, lymphocytes, macrophages, and possibly bone cells). These changes may lead to a reduction in the number of these cells and so affect the cells ability to repair itself.

Kidney disease has become more prevalent over the years, one in nine Americans has chronic kidney disease, resulting in the need for a kidney transplant. Kidney failure is caused by variety of factors resulting in damage of the nephrons, which are the most important functioning unit of the kidneys. Kidney failure can be broken down into three groups: acute, chronic, end-stage. Once kidney failure is irreversible, dialysis or transplantation is the only method of survival. To avoid a kidney transplant, one needs to be aware of the pre-disposing factors, signs and symptoms, available treatments, and proper diet.

Kidney disease can affect children in various ways, ranging from treatable disorders without long-term consequences to life-threatening conditions. According to Inker et al. (2014), Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines defines acute renal failure (ARF) as the sudden loss of kidney function, generally occurring over the course of hours to days and resulting in the retention of metabolic waste products and dysregulation of fluid, electrolyte, and acid-base homeostasis. The purpose of this paper is to describe pathophysiology of ARF, to discuss specific developmental impact on adolescents with ARF, to review the different teaching methods for family and adolescents to increase compliance, and to identify different

Mr. Armstrong has a history of renal insufficiency and uncontrolled hypertension, along with symptoms of fatigue, pedal edema, and occasional shortness of breath. He does not have a history of trauma or obstruction to his kidneys, but his creatinine and BUN levels are currently at 3.5 mg/dl and 40 mg/dl. Normal creatinine concentration values are 0.7 to 1.2 mg/dl and normal BUN values are 10 to 20 mg/dl; this reveals that Mr. Armstrong’s kidneys are not removing wastes properly (McCance, Huether, Brashers, & Rote, 2014).  Mr. Armstrong’s history of renal insufficiency and uncontrolled hypertension is commonly found in patients diagnosed with intrarenal (intrinsic) acute renal failure. Intrarenal acute renal failure can be categorized as

Organ transplantation is a medical act which involves the surgical operating by transferring or removing of an organ from one person to the other, or placing the organ of a donor into the body of a recipient for the replacement of the recipients damaged or failed organ which resulted from impairment of normal physiological function affecting part or all of an organism or an act that causes someone to receive physical damage.

to the patients.21 For example, BK viral occurs ''in the urine and can cause inflammation and

To understand what renal failure is, it is important to know how the kidneys work and what the main functions are. The body has two kidneys on either side of the spine and the kidneys work to remove toxic waste and excess water by producing urine. The kidneys also help with controlling blood pressure and produce erythropoietin as well as aiding in keeping bones strong by producing calcetrol hormones. When the kidneys are unable to perform these functions it causes the kidneys to fail.