SLE: Pathogenesis, prevalence, and affected individuals. In general, the term “lupus” is used to describe a multi-systemic inflammation that results from an abnormal immunological function. It includes four main types: neonatal and pediatric lupus erythematosus (NLE); discoid lupus erythematosus (DLE); drug-induced lupus (DIL); and systemic lupus erythematosus (SLE). The latter is the most common type, and it is referred to simply as “lupus”. SLE is a complex rheumatic disease of an autoimmune origin, with an unknown etiology and thus individuals at risk are unable to prevent the disease’s progression. Genetic, hormonal, environmental factors as well an immunological abnormalities have been contributed to its pathogenesis. The most agreed upon theory is that the diseases develop as a consequence of the formation and deposition of autoantibodies and immune complexes in various organ systems, leading to eventual organ damage. Studies focusing on SLE as a genetic diseases have shown that there is a genetic predisposition within families. For example first-degree relatives of patients with SLE are significantly more likely to have the disease compared to the rest of population (Maidhof & Hilas, 2012).Recent technological advances have led to breakthroughs in the identification of susceptibility factors involved in SLE, among which DNA methylation alterations has shown great potential. Incomplete concordance for SLE has been found in homozygotic twins, suggesting that
Lupus is a chronic inflammatory disease of unknown cause that can affect virtually any part of the body. The medical term for Lupus is Systemic Lupus Erythematosus or better known as SLE. With Lupus there is a malfunction in some of the cells of the immune system. "In Lupus, the body overreacts to an unknown stimulus and makes to many antibodies, or proteins directed against body tissue. Thus, Lupus is called an autoimmune disease. ”#
Lupus is an autoimmune disease that attacks women between the ages of 15 and 40. It occurs less often in men than in women. The people affected by lupus vary depending on the country or region. In the US alone, the prevalence rate is highest among Asians of Hawaii, blacks of Caribbean origin, and Native Americans of the Sioux, Arapahoe, and Crow tribes. Lupus is a disease that affects the immune system. We can think of the immune system as an army within the body with hundreds of defenders (known as antibodies). They defend the body from attack by germs and viruses. In lupus, however, the immune system becomes overactive and creates antibodies that attack healthy tissues in the body, such as: the skin, kidneys, lungs, heart and brain.
This document will discuss how demographics disease trends affect the delivery of health care. Starting with current age composition of the United States population and how future changes will occur in the next 10 to 20 years. Next will be identifiable factors that support environmental and changing demographic trends. Providing examples of relevant diseases and how the aging trend will increase or decrease health issues and how to reduce health complications because of age. The current rate of obesity will be discussed and how it will change in the next 10 to 20
Juvenile lupus is a “disease in which the immune system is overactive and does not function properly” (College of Rheumatology). As with many autoimmune conditions, the immune system attacks healthy tissues. In the case of juvenile lupus the immune system attacks different organs in the body, which results in painful inflammation in the child (College of Rheumatology). There are multiple possible factors included in the cause of juvenile lupus, like hormones and the environment, but because the cause of lupus is still unknown, no one really knows how to prevent it from happening in children (College of Rheumatology). There is no cure for lupus, but there are many successful treatments to help children and teens with juvenile lupus (College of Rheumatology).
as for familty history it is believed that Heretity plays a roll in lupus. With other known medicals problems similiar to those such as enemia and other autoimmune diseases it is suspected the two are intertwinned. while no factual proof leads to this assummtion it seems to be somewhat of a common occurance between
Systemic lupus erythematosus (SLE) also referred to lupus dates back to the middle ages and has made an explosion in the past 60 years. Even though more than 1.5 million Americans have lupus and 90% of lupus sufferers are women, between the ages of 15 to 44 (Lupus Research Institute), there is little awareness about the disease. 72% of Americans aged 18-34 have either not heard of the disease or know nothing about it (Medical News Today). However, researchers continue on working to have a better understanding of SLE factors, pathophysiology, current treatment and new prospects for treatment.
Systemic Lupus Erythematosus is an autoimmune disease within the appearance of autoantibodies that fights against nuclear antigens within the body of a person who is living with SLE and the involvement of their organ systems, including the kidneys. The rigorous events that cause an onset of medical signs of SLE are not yet well understood. However, the researcher are usingnumerous mouse strains spontaneous and inducible lupus to find a cure because as of now there still is no cure for lupus.
The exact cause for Lupus is unknown; however experts believe that some people are born with certain genes that affect how your immune system works. It appears that people with inherited predisposition for Lupus may develop this disease when they come in contact with “triggers.” Some potential triggers are: sunlight, infections, and medications. Sunlight exposure can lead to Lupus skin lesions, or trigger and internal response in susceptible people. Having an infection can initiate Lupus, or causes a relapse in symptoms. Also some anti-seizure, blood pressure, and antibiotic medications can trigger Lupus. People who have drug induced Lupus noticed their symptoms go away once they stopped taking the
Autoimmune diseases materializes when the immune system becomes perplexed and vicious assault the human body, devastating tissue. Thus, both Lupus and RA (Rheumatoid arthritis) are destructive autoimmune diseases. Nevertheless, it is currently undetermined what activates these diseases, but they are regrettably genetic in nature. Both diseases coalesced affect approximately 24.2 million Americans. Though they share similar symptoms, each has its unique way of inflicting excruciating and debilitating discomfort to the human body. This essay will explore the similarities and variances between the two.
The cause of Lupus is still an enigma, and this is one chronic condition that still can’t be easily defined.
Discoid Lupus Erythematosus (DLE)is an autoimmune disease that affects the skin, DLE causes skin rashes and lesions on the scalp, internal ear, nose, and cheeks, unfortunately, hair loss and skin pigmentation occur with this disease. This rare disorder seems to be more common in women (between the ages of 20-40) than in men and is hereditary. Ten to twenty percent of people (around 200,000 US population) who have DLE will develop its more severe cousin ASLE (acquire systemic lupus erythematosus) which can be life threatening.
Lupus is an autoimmune disease in an overly active state that attacks healthy, functioning tissue. This disease is not well known mainly for two reasons, firstly, it is not given enough hype in social media. Secondly, many people show symptoms during the early stages of lupus however, the victims do not recognize its severity until the disease has afflicted permanent damage. This is usually because some symptoms are similar to other less threatening ailments. Lupus affects many systems of the body which include the gastrointestinal system, the cardiopulmonary system, the musculoskeletal system, the renal system, and the integumentary system. This disease is formerly caused by genetic inheritance however, there are a great number of factors that trigger the immediate onset of lupus, as it is not necessarily prevalent on a person who has the genes from birth. Although there is no known cure for lupus, efficacious forms of treatment are possible.
Makover, M. & Zieve, D. (2011, February 14). Systemic Lupus Erythematosus. National Center for Biotechnology Information. Retrieved July
Lupus is a chronic inflammatory disease marked by its effect on various parts of the body, including the joints, skin, blood, and kidneys. It is a condition in which the body's immune system attacks its own cells and tissues, resulting in pain, inflammation, and often damage to organs. Lupus involves the immune system. The immune system makes antibodies that work to protect the body against foreign substances like viruses and bacteria. Such foreign bodies are called antigens. When a person has lupus, his or her body is unable to determine the difference between antigens and the individual's cells and body tissues. As such, the immune system creates antibodies against the individual's own tissues. These antibodies are called autoantibodies. Depending on the type of lupus, a wide range of symptoms may be experienced, from rashes, hair loss, and achy, swollen joints to fever, anemia, and abnormal blood clotting. Though the disease can affect many parts of the body, individuals usually experience symptoms in only a few organs. There is no known cure for lupus. However,
“Epidemiology is the study of the distribution and determinants of health-related states or events (including disease), and the application of this study to the control of diseases and other health problems (WHO, 2015)”. “Various methods can be used to carry out epidemiological investigations: surveillance and descriptive studies can be used to study distribution; analytical studies are used to study determinants (WHO, 2015)”.This paper discusses about epidemiology of HIV infection, including factors that contribute the development of the disease, epidemiologic triangle, role of community health nurse and the national organization that address the communicable disease.