Pathophysiology Of Diabetes Mellitus And Diabetes Essay

1189 Words5 Pages
Pathophysiology of Diabetes Mellitus Diabetes Mellites(DM), is a deficiency of insulin action causing hyperglycemia. The majority of DM have a decreased secretion of the cells, insulin resistance, or counterregulatory hormones( McPhee & Hammer, 2010). Insulin is synthesized from the beta cells from the pancreases. Composed from A peptide and B peptide connected to C peptide and disulfide bonds. Insulin is a hormone that aids in metabolism. encourages glucose uptake and the synthesis works mainly in the liver, muscle, and adipose tissue (Huether & McCance, 2012). Hyperglycemia occurs when glucose levels are past the threshold for the renal system to reabsorb glucose. Causing polydipsia, polyuria, polyphagia( McPhee & Hammer, 2010). Diabetic Ketoacidosis(DKA) is from metabolism of fats and proteins with increasing ketones in the circulation(Huether & McCance, 2012). The loss of insulin activity increasing serum glucose levels due to hepatic glucose output and decreased glucose uptake. DK occurs in both type 1 and type 2, type 1 is due to lack of endogenous insulin. Type 2 occurs decreasing the insulin action due to infections, trauma, or increased stress, which can cause coma, due to the hyperosmolality ( McPhee & Hammer, 2010). Hypoglycemia symptoms occur secondary to the release of catecholamine. Symptoms are shaking, sweating, palpitations, with worsening into further issues of neuroglycopenic symptoms, such as confusion and coma, night sweats, nightmares, and
Open Document