Pathophysiology Of Leukemia

– Increased WBC will indicate infection, or secondary to trauma (stress reaction); in rare cases may signal hematologic disturbance (i.e., leukemia)

Being diagnosed with a serious illness such as cancer as a child/young person can also prove to lead to developmental issues. All areas of development can be compromised, intellectually, through missing school and being too ill to complete set work. They may suffer physically depending on the specific illness causing them to be weak and/or in too much pain and discomfort to complete physical activities. Socially they may be too ill to interact with others and/or maintain friendships. They may also become emotionally withdrawn and find it difficult to cope with their emotions.

Acute Lymphoblastic Leukemia, is the disease that affects children the most and because of the abnormal cells that are immature white blood cells which cannot help the body fight infections cause children with the disease to often get infections and have fevers (National Cancer Institute, 2002, p. 1). The symptoms that the patient with ALL may have depend on the number of abnormal cells of the patient where exactly the cells collect. Children patients with ALL have low amounts of healthy red blood cells and platelets, which cause less oxygen to be carried through the body because of the lack of red blood cells. Patients at times may look pale, feel weak, and tired causing bleeding and bruising very easily because of their lack of enough platelets. This condition is called anemia. Anemia is very much common in patients with acute lymphoblastic leukemia. Fever, fatigue, bone or joint pain, tiny red spots under the skin called petechiae are a couple of symptoms that the disease ALL has. Headaches with, or without vomiting also may occur if patient happens to have abnormal cells collecting in the brain or spinal cord (National Cancer Institute, 2002 para. 2).

Symptoms that can be in Hodgkin disease (lymphoma) like there is small red spots under the skin which is called petechlae, frequent infections, easy bruising or bleeding, headaches, trouble breathing, joint and bone pain, not hungry or short appetite, sweating while sleeping, weight loss, chills, fever. Anemia is a low red blood cell count. Red blood cells carry oxygen around the body. Their condition could help out in the weakness or the shortness of the breath. Leukopenia is a low white blood cell count. It is a decrease in a production of functional leukocytes (white blood

Myelodysplastic syndromes occur when blood cells are misshapen and dysfunctional. These syndromes generally do not cause symptoms in the beginning, but as they progress the signs and symptoms make themselves known. Some symptoms include shortness of breath or difficulty breathing, fatigue, pallor, petechiae, abnormal bleeding and bruising, and

Leukemia is cancer in the bone marrow and the lymphatic system and affect the body's blood-forming tissues. Leukemia usually involves white blood cells. Your white blood cells fight off infections. People with leukemia, the bone marrow produces abnormal white blood cells, which don't function properly. Scientists don't understand the exact causes of leukemia. It is believed to develop from a combination of genetic and environmental factors. In general, leukemia is thought to occur when blood cells acquire mutations in their DNA. The CD34 phenotype. Certain abnormalities

When someone has leukemia the white blood cells that form can not help the body fight off infections. With leukemia people might have frequent infections and have flu-like symptoms, such as fever and chills. If the cells multiply and move

The symptoms of Acute Lymphoblastic Leukaemia usually begin slowly before rapidly getting severe as the number of blast cells in the blood increase. Most of the symptoms are caused by the lack healthy blood cells in the blood supply. Symptoms of this disease include: pale skin, feeling tired and/or breathless, having repeated infections over a short period of time, unusual and frequent bleeding, such as nosebleeds and bleeding gums, high temperatures, night sweats, bone and joint pain, easily bruised skin, swollen lymph nodes, abdominal pain caused by a swollen liver or spleen, unexplained weight loss, and a purple skin rash or also known as a purpura. The symptoms could relate to a different illness or maybe just a common cold. Although they are quite common, they could be a path to an extremely cruel

As Leukemia cells build up in the marrow, they can crowd out the normal blood cell-making cells. The Leukemia cells might also invade other areas of the body, which can also cause symptoms. A few symptoms of Leukemia are tiredness, coldness, weakness, feeling dizzy or lightheaded, headaches, and shortness of breath and pale skin. If you have low blood plate counts you could also have bone or joint pain, swelling of the abdomen, loss of appetite or weight loss, swollen lymph nodes, coughing or trouble breathing, swelling of the face or arms, headache, seizures or vomiting, rashes, gum problems, extreme fatigue, and weakness. Children who receive therapy for all types of Leukemia may also experience their own symptoms, which may include late adverse effects, which are central nervous system (CNS) impairment, slowing of growth, infertility, cataracts, and an increased risk for other cancers. These effects vary on the person’s age during the treatment, and the type of therapies that they

Though most of these symptoms are caused by many things other than leukemia it is still very important to alert your doctor when you notice these things, as it may be crucial in detecting a problem in your child. Your doctor will then be able to move forward with gaining medical history and conducting a physical exam where they may look for swollen lymph nodes, areas of bleeding or bruising and signs of infection. Feeling the belly for swollen spleen or liver signs and thoroughly checking the eyes the mouth and the nervous system. Following the physical exam a finger prick may be obtain along with a blood sample. If test come back with abnormalities and bone marrow sample will need to be taken for sure. When the bone marrow samples are taken a biopsy is done usually at the same time. Doctors may also use a number of other test along with imaging test.

Get the reader’s attention. Set the scene. Who is involved? When and where did the event take place? Parents Sara and Brian Fitzgerald have a daughter Kate who at the age of two was diagnosed with a rare and aggressive form of leukemia.

The first symptoms are usually non- specific and include anorexia, irritability and lethargy. Fever is the most common finding, occurring in approximately sixty percent of patients. Progressive bone marrow failure leads to anemia,

Cancer originates from a cell that becomes an abnormal cell. Abnormal cancer cell spreads to disintegrate your tissue lowering immune system (Human Origin 2005). An example of cancer is leukemia. Leukemia is a type of cancer that concerns with the blood flow on bone marrow. According to Maggie Grundy (2000), leukemia is a forming tumor that moderately increases as of the blood cells that has been infected, it’s also a cancer that affects the bone marrow where blood cells are produced.

Leukemia is a malignant disease of your blood cells caused by excess of white blood cells also known as leukocytes in the blood. The abnormal accumulation of white blood cells that starts in the soft and inner part of the bone (bone marrow) often moves quickly into the blood and spread to the other parts of the body that causes problems as they crowd out the red blood cells and platelets in which your body needs to be healthy. Blood has three types of cell: White blood cells are the cells of the immune system that fight infection, protecting the body against both infectious disease and foreign invader. Red blood cells which is made in the bone marrow carries oxygen to be transported around the body and also remove carbon dioxide from

I am Gino Dettorre, and I will be a senior at Bishop Watterson High School this coming school year. Currently, I am interested in pursuing a major in biology with a minor in Spanish at either Washington University in Saint Louis, University of Pennsylvania, or Vanderbilt University. While participating in the Mechanisms of Human Health and Disease program at Children’s Hospital, I have gained a better understanding of the molecular bases of various diseases, and I am interested in applying this knowledge in a laboratory setting. I have chosen to research acute myeloid leukemia because I have known relatives and friends affected by blood cancers, and I am interested in better understanding the mechanisms of this disease.