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Pathophysiology Of PTSD

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Method-Studies were identified by means of computerized and manual searches. The review of research on the pathophysiology of PTSD and substance use disorders was focused on studies of the hypothalamic-pituitary-adrenal axis and the noradrenergic system.

Results- High rates of comorbidity suggest that PTSD and substance use disorders are functionally related to one another. Most published data support a pathway whereby PTSD precedes substance abuse or dependence. Substances are initially used to modify PTSD High rates of comorbidity suggest that PTSD and substance use disorders are functionally related to one another symptoms. With the development of dependence, physiologic arousal resulting from substance withdrawal may exacerbate PTSD
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