Pcb Case Study

Following the 2001 Stockholm Convention on Persistent Organic pollutants, by 2008, 160 nations signed the agreement to eliminate DDT, considered one of the twelve pollutants of “greatest concern to the health of the global community” (Eskenazi et al., 2009). Despite unease about the lasting effects of DDT, the insecticide should not be banned completely.

Primary hypertension can be linked to several risk factors, some in which are evident in K.H.’s history and

Hypertension, also known as high blood pressure, has become a major risk factor for several types of heart disease across the globe. In the United States alone, nearly 70 million adults have been diagnosed with this condition [1]. Hypertension is a condition in which arterial walls experience extreme force from blood flowing through; long-term force against artery walls will lead to more serious health problems such as stroke, renal failure, and other cardiovascular diseases [2]. If the proper steps to treat hypertension are not taken, patients have a high risk of developing atherosclerosis, a condition that causes arteries to harden significantly. Smoking, obesity, lack of physical activity, high alcohol consumption, and high sodium intake are factors that may cause an individual to be diagnosed with hypertension [3] Detection of hypertension is crucial in order to reduce the incidence of death by cardiovascular disease [1].

The major health problem selected for this project was hypertension (Harrison et al, 2011). It is identified as a cardio vascular disease risk factor such as dementia, chronic kidney disease, coronary heart disease, and stroke (NICE, 2011). It can be missed easily, as in various instances it is asymptomatic as well as it is also known as a silent killer. The Hypertension is thought to be a disease of vascular regulation ensuing from arterial pressure control mechanisms malfunction (extracellular fluid volume, rennin-angiotensin-aldosterone system, and CNS) that results in elevation of BP by means of enhanced peripheral vascular resistance, and cardiac output. There are 2 basic hypertension types. Around 90 to 95 percent of the individuals have primary hypertension which is linked with change in lifestyle as well as needs medical treatment. On the other hand, 5-10% has secondary hypertension which is linked with various other diseases for instance pregnancy, thyroid, and renal (Haslam and James, 2005). It is estimated that around 1 in 20 adults will have increased BP of 160/100 mmHg and above that results in either more than one predisposing aspects (Gemmell et al, 2006).

Between 2002 and 2005 alone, the amount of chemical substances produced or imported in the United States increased from 42 billion pounds per day to 74 billion pounds per day. The amount of chemicals in commerce in the United States has increased from 62,000 grandfathered chemicals in 1976, to almost 83,000 in 2008, a difference of more than 20,000. Of this 83,000, the EPA has only been able to ban or restrict five chemicals under TSCA: PCBs, dioxin, CFCs, hexavalent chromium, and asbestos. Additionally, the EPA has independently tested only 250 of the 83,000 registered chemicals in commerce in the United States. Richard Denison, a Senior Scientist for the Environmental Defense Fund explained these incredibly low numbers by stating, “TSCA places an impossibly high burden on EPA before it can act to control a chemical.” In fact, under TSCA, “the EPA can’t even require testing to determine whether a risk exists without first showing a risk is likely.” For that reason, a large majority of chemicals used in the United States have never been tested for health and environmental effects. Studies have shown that due to the proliferation of these chemicals into homes, workplaces, and schools, the average American has a detectable concentration of 300 environmental chemicals. Among other issues, many of these chemicals can affect brain and organ function and cause cancer. Consequently, it is clear that

Hypertension is sometimes referred to as the silent killer (Aycock, Kirkendoll, & Gordon, 2013). Today it is a public health problem. According to the American Heart Association 2013 Statistical Fact Sheet (2013), one out of every three adults has high blood pressure, which is estimated at 77.9 million people (AHA, 2013). High blood pressure is also referred to as hypertension. Hypertension is a prevalent medical condition that carries with it the risk factor for increased chances of heart disease and stroke (Gillespie & Hurvitz, 2013). Hypertension remains one of the top 10 causes of worldwide disability-adjusted life years (as cited in Drenjančević-Perić et al., 2011). For the estimated 348, 102 deaths in 2009, high blood pressure was listed as the primary or contributing cause of death (AHA, 2013). Despite the health risk associated with hypertension, the diagnoses of high blood pressure continue to rise. By 2030, hypertension is expected to increase by 7.2% from 2013 estimates (AHA, 2013).

Blood pressure is taken in order to assess any precautions for treatment. An elevated blood pressure between the ranges of 130-139/85-89 mmHg is known as prehypertension. Prehypertension is a health concern due to an increase risk for cardiovascular disease and organ damage if continued left untreated. Cardiovascular related events associated with prehypertension include heart failure and myocardial infarction. Prehypertension can be caused by an increased amount of stress, lifestyle changes, or can be caused by a secondary disease. Factors that can influence high blood pressure include obesity, smoking, alcohol, excessive sodium intake, lack of physical activity, and diet. Secondary diseases associated with high blood pressure include diabetes mellitus and kidney disease.

(2012), it was verified that the increased prevalence of chronic kidney disease is a consequence of the accumulation of risk factors, one of which is hypertension. It is also associated with increased risk of not only progression to renal failure but also excess cardiovascular morbidity and mortality in a manner independent of other known risk factors (Yano et al., 2012). The research was conducted with 232,025 patients in a Japanese nationwide database with a focus on the prevalence and risk factors of chronic kidney disease in prehypertension. The prevalence of chronic kidney disease among patients with hypertension was 20.7% in men and 15.0 % in women (Yano et al., 2012).

American Heart Association quotes that Hypertension is an important public-health challenge worldwide. Importance should be focused on its detection, treatment control and prevention. The infectious diseases such as malaria and tuberculosis which once were the reasons for leading the causes of deaths have been replaced by non –infectious diseases which are mostly the NCD’s such as diabetes, heart diseases, and other vascular conditions. Hypertension is an important worldwide public-health challenge because of its high frequency and concomitant risks of cardiovascular and kidney disease [78][79]. Heart attacks and strokes are major–but preventable–killers worldwide. More than 80% of cardiovascular disease related deaths take place in low-and

Dioxin (polychlorinated dibenzodioxin), commonly known as 2,3,7,8-tetrachlorodibenzo-para-dioxin (2,3,7,8-TCDD), is a group of aromatic hydrocarbon compounds known to be environmental pollutants. Dioxins are produced as a by-product during the manufacturing and burning of plastics (Clancy, Farrow, Finkle, Francis, Heimbecker, Nixon-Ewing, et al., 2011, p. 338). There are many different dioxin compounds, each having different levels of toxicity. Dioxin is commonly referred to as TCDD because it is the most toxic and well studied form of dioxin. Dioxins are characterized by the presence of two benzene rings that are connected by a pair of oxygen atoms. Each of the eight carbon atoms that are not bonded to oxygen is able to bind with hydrogen atoms or other elements. The more toxic dioxins carry chlorine atoms. 2,3,7,8-TCDD is extremely stable and virtually insoluble in water, but soluble in oils. This allows dioxin in soil to resist dilution with rainwater. If it is absorbed, it is able to enter the fatty tissue in the body. This chemical is created by the burning of chlorine-based chemical compounds of some industrial, non-industrial, and natural processes that involve combustion. They are also generated as by-products from the manufacturing of herbicides, disinfectants, and other agents, and usually form as a by-product in the majority of all combustion processes.

During recent years, numerous newspaper and magazine articles have suggested that humans may be at risk because small amounts of well known environmental contaminants, such as dioxin, PCBs and DDT, can affect hormone levels. Hormones are produced by the endocrine system as regulators of biological function in target organs. Because hormones play a critical role in early development, toxicological effects on the endocrine system often have an impact on the reproductive system. The term endocrine disruptor is used to describe chemicals that can mimic hormones and may either enhance or counteract their effects. It has been suggested that these hormone changes can, in turn, lead to a variety of health problems

Hypertension is widely considered to be one of the most important risk factors of cardiovascular diseases (angina, arrhythmia, etc.). It is the second leading disease that causes mortality in the world. Hypertension is the condition when there is an increase in the force of blood on the walls of vessels. It can also be defined as an arterial blood pressure that is raised above 140/90 mm Hg (systolic/ diastolic BP). Hypertension can be classified into Secondary hypertension and Essential hypertension. When specific cause is evident but heredity, and various physiological parameters play a role in increasing blood pressure is known as Essential Hypertension. Secondary Hypertension is one where the cause is known. According to WHO guidelines between 2006 and 2015, deaths due to cardiovascular diseases are expected to increase by 17% while the deaths from infectious diseases, nutritional deficiencies, maternal and prenatal conditions are projected to decline by 3%. The main causes of hypertension includes the age ,hereditary, gender, extra weight, alcohol consumption, stress life, lazy life etc.

Approximately one in every three adult’s ages 20 years old and older are diagnosed with high blood pressure or hypertension. Hypertension affects 78 million people in the United States and is equally prevalent in both men and woman (Crabtree et al., 2013). Hypertension is a major risk factor for cardiovascular disease (Hajjar & Kotchen, 2003). It can lead to stroke, myocardial infarction, renal failure, heart failure, neurological issues, and death if not detected early and not treated properly (James, Oparil, Carter, & et al., 2014). Approximately 9.4 million deaths in 2010 were attributed to high blood pressure (Angell, De Cock, & Frieden, 2015). About 54% of strokes, 47% of coronary heart disease, and 25 % of other cardiovascular diseases are attributed to high blood pressure (Arima, Barzi, & Chalmers, 2011).

The two major types of hypertension are primary and secondary. Primary hypertension accounts for more than 90% of all cases and has no known cause, although it is hypothesized that genetic factors, hormonal changes, and the altercations in sympathetic tone all may play a role in its development. Secondary hypertension develops as a consequence of an underlying disease or condition. The prevention and treatment of hypertension is a major public health issue. When blood pressure is controlled, cardiovascular, renal disease, and stroke may be prevented. The JCN, reported more than 122 million individuals in American are overweight or obese, consume large amounts of dietary sodium and alcohol, and do not eat adequate amounts of fruits and vegetables; less than 20% exercise regularly. Both modifiable and non-modifiable factors play a role in the development of hypertension

PCB’s (polychlorinated biphenyls) and dioxins have been in focus recently as there are concerns that the different structures are appearing to mimic the effects of female oestrogenic hormones. (Gray 1996) These chemicals can cause genetic chromosomal problems and major concerns to the reproductive effectiveness of marine animals. Oil spills and the burning of wood and coal can cause poly-aromatic hydrocarbons (PAHs), which has a negative effect on all wildlife causing genetic abnormalities. (EMCBTAP-ENVIS Newsletter 2002).