Pediatric Head And Neck Squamous Cell Carcinoma Of Oral Cavity And Oropharynx

Squamous cell carcinoma is the second most common form of skin cancer. Arising from keratinocytes of the stratum spinosum lesions. These lesions often appear, scaly red patches, reddened, or elevated eventually forming a conclave ulcer with elevated edges. If detected early and surgical removal the chances of recovery are high.If neglected and undetected cancer can metastasize spread to the lymph nodes and become deadly (Saladin,

Radiation is known to damage the parotid glands and surrounding tissues, resulting in various toxicities which can lead to a functional decline in swallowing. The current study examined the incidence, nature and severity of treatment-related toxicities in patients with PGC undergoing XRT and found a trend of acute toxicities and swallowing difficulties that deteriorated throughout the course of XRT and peaking at the end of the treatment. Whilst this pattern of toxicity presentation and recovery is similar to other HNC groups, the severity of toxicities presenting in this clinical group was much lower, with few patients having any persistent difficulties at 3 months post treatment. The current information can be used to develop models of

Radiation to the head and neck includes oral problems including mucositis, taste loss, loss of

April 20th 2011 was the date of the discovery. A cause of SCC is associated with Human papilloma virus, with the oropharynx, lung, fingers, and anogenital region. Exposure to sunlight could also be another cause to SCC, you have to have protection on your skin. With this kind of exposure it is the strongest environmental risk factor. Squamous Cell cancers of the lip and ears are high rates of recurrence and distant metastasis. Individuals on immunotherapy or suffering from lymph proliferative disorders(leukemia) tend to be much more aggressive, regardless of the location. The symptoms might have are highly variable depending on the organ it is on. Lesion caused by SCC is often asymptomatic. Reddish skin blotches that are slowly growing is another sign. If the tumor continuously bleeds especially on the lip, that is another symptom you could look for. Usually the tumor shows as an ulcerated lesion with hard raised edges. Also your tumor grows relatively slowly. A way for SCC to be treated is by surgery. If the doctor diagnoses the cancer they will quickly take you to get it removed. It is almost always curable and it causes minimal damage. But if it

(surgeon continues with a smile)…..who is very active in his career. This is a simple case of early stage hypoparynx. Tumor is less than 2cm and was measured at 1.4cm he has only a single lesion in hypopharynx, and we did not see positive lymph nodes. He will be having surgery and we will put him on a smoking cesation program immediately.

While pursuing my degree at HSDM, I gained enormous experience by practicing oral medicine at the Brigham and Women Hospital in which I acted as a primary care providerprovided care for patients with various diseases of the head and neck, including oral and maxillofacial, odontogenic, and non-odontogenic, diseases, including but not limited to infectious, vesiculo-bullous, auto-immune diseases, Sjögren syndrome, and chronic graft versus host disease. I also collaborated competently and effectively in the health care environment as a member of a multi- disciplinary health care team to facilitate the provision of health care, through participations in tumor boards, seminars, and teaching rounds during medical rotations. In addition, I participated

Oral malignant melanoma of the mouth is an extremely rare tumor arising from the uncontrolled growth of melanocytes found in basal layer of oral mucous membrane. Melanocytes are neural crest derived cells that migrate to the skin, mucous membrane and several other sites. It was first described by weber in 1859. Its incidence is estimated to vary widely between 0.2% and 8% of all melanomas and 1.3% of all cancers. Approximately 80% of oral melanomas arise in mucosa of upper jaws in elderly patients with majority occurring on keratinizing mucosa of the palate and alveolar gingivae. Other sites include buccal mucosa, mandibular gingivae, tongue and floor of the

Remission- the reduction or disappearance of cancer signs and symptoms; may be partial (some) or complete (all) remission.

Cancer of the floor of the mouth occurs when cells under your tongue become abnormal and start to grow out of control. This usually starts in very thin, flat cells that line the surface of your mouth (squamous cells). Cancer cells can spread and form a mass of cells called a tumor. The cancer may spread deeper into the floor of the mouth, or it may spread to other areas of the body (metastasize).

Cancer of the head and neck are diagnosed each year with a high incidence of laryngeal cancer. Maddox and Davies (2012) reported that, “The estimated number of Laryngectomies performed in 1997 was 5,038, this number dropped steadily to a low of 2,966 in 2006 and then rose slightly in 2008 to 3,414”.Men and women both seek surgery to alleviate the problem. Total laryngectomy is undertaken in as many as 50% of patients with a relative survival rate of 52% with no significant

Evidence for a causal involvement of HPV in the pathogenesis of OPSCC comes from epidemiologic and molecular studies. The earliest suggestion of a possible link between HPV and squamous cell carcinomas of the oral cavity (OSCC) was made by Syrjanen et al (1983) where the group observed that some of these tumours have morphological and immunohistochemical features indicative of HPV infection. 59 Subsequent studies have supported the predilection of the virus for oropharyngeal cancers. In two case series (1996 and 1997), 50% and 60% of tonsillar carcinomas were HPV positive, respectively, in comparison to 6% and 10% of tumours at other oral sites.60,61 Additionally, Gillison et al (2000) and Stransky et al (2011) confirmed that the only HNC subsite with a demonstrated carcinogenic role for HPV was the oropharynx.21,62

Nasopharyngeal carcinoma (NPC) has important and distinctive clinicopathological features in the field of head and neck pathology. The existence of a swelling in the upper half of the neck that occurs due to cervical lymph node enlargement should warn the physician to a possible nasopharyngeal carcinoma regardless of race or geographical location. Examination of the nasopharynx is essential and must be carried out with great care, using special equipment if necessary. Biopsy of the nasopharynx should be carried out in all suspected cases, even if no tumor is seen. In difficult cases, the diagnosis may be aided by special diagnostic techniques including serology and imaging. A careful planned diagnosis will avoid misdiagnosis. There is a high

Historically, surgery and radiotherapy were the mainstays of therapy for nasopharyngeal cancer .Due to the difficulty of the surgical approach to the nasopharynx and the difficult excision of tumors in this location with adequate margins, radiotherapy has become the primary modality since 1950.

Salivary gland tumors are a morphologically diverse group of neoplasms, which may present considerable diagnostic and management challenges for the pathologist and surgeon. Salivary gland tumors are rare with an overall incidence in the western world of about 2.5 to 3.0 per 100,000 per year. About 80% of all lesions are benign; hence salivary malignancies are particularly rare, comprising less than 0.5% of all malignancies and about 5% of cancers in the head and neck. (1)

The literature review was detailed explaining the etiology diagnosis and treatment of the disease however limited literature references were mentioned to support the conclusion that, Oral cavity lesions can be the first sign of relapse or succession of myeloma.1