Pediatric Head And Neck Squamous Cell Carcinoma Of Oral Cavity And Oropharynx

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Head and Neck squamous cell carcinoma of oral cavity and oropharynx in children: Report of 10 cases and illustrated review of literature.
Introduction
Pediatric head and neck squamous cell carcinoma (PHNSCC) (defined as <20 Years) is a rare entity accounting for <2% of all pediatric malignancies put together. [1] In adults these tumors are mostly associated with tobacco abuse or Human papilloma virus [HPV] infection. However, the etiology remains largely unknown for pediatric patients. In comparison to adults, disease biology, management approaches and tolerance to treatment may profoundly vary necessitating a better understanding of this less known subset. Treatment approaches have been extrapolated from the adult HNSCC and surgery remains the standard of care followed by adjuvant radiotherapy or radio-chemotherapy as indicated. Radiation with or without chemotherapy have been used in oropharyngeal primaries. We herein present our experience in treating 10 patients of head and neck squamous cell carcinoma of oral cavity and oropharynx of < 20 years and reviewed the published literature to consolidate treatment schema of such cases.
Materials and methods:
We retrospectively analyzed the treatment charts of patients of HNSCC treated at our institute from 2006 to 2014. A total of 5000 cases were registered during this period. Patients of head and neck squamous cell carcinomas (Oral cavity, Oropharynx, Hypopharynx, Larynx) under the age of 20 years were taken up for analysis.

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