Pemphigoids Essay

I chose to write my professional paper on syphilis, with a focus on congenital syphilis (CS), not only because I plan on practicing mid-wifery, but because I enjoy anything that has to do with reproduction and congenital abnormalities.

Syphilis is a rare sexually transmitted disease that causes serious health problems and complications if left untreated. This disease has stages and many symptoms. Both genders can contract it, but it can be cured and certainly prevented.

58) Connective tissues that possess a large quantity of collagen fibers often provide the framework for organs such

Sometimes, an electron dense thin line can be seen underneath hemidesmosomes, outside the cell and adjacent to the plasma membrane. This structure is referred to as the sub-basal dense plate. The hemidesmosome is composed of at least 5 distinict molecules: (1) bullous pemphigoid antigen 1 (BPAG1), (2) plectin, (3) integrins, (4) collagen XVII (BPAG2) (5) CD151. The first two molecules, BPAG1 and plectin, are found within the basal keratinocyte, and have been localized to the inner plaque of the hemidesmosome.[13]

Psoriatic arthritis is a form of arthritis that affects certain people. It is normally characterized by red patches on skin and scale like features. This disease develops differently, with some people contracting the psoriatic arthritis first before the joint pains and vice versa. As per now, there is no known cure for this disease. Obesity is acondition were the health of an individual is put at risk because of body fat that accumulates in the body. Over the years doctors have discovered growing cases of people with both diseases. The major difference was that psoriatic arthritis was worse in people that are overweight or obese they have a harder time because of how much they weigh. Recent research also proves that unlike their counterparts that weigh normally, obese people are less likely to reach minimal disease activity in a year. This can be explained in a variety of ways.

also. The only way to keep irritants from triggering eczema is to avoid them by

To understand autoimmune diseases, the general characteristic of autoimmunity must be addressed. Autoimmunity is defined, in short, as “ misdirected immune response”. A healthy person is equipped with the mechanisms necessary to defend the body from pathogens within the immune system. When autoimmunity is present in an individual, something within the immune system is

Dermatitis is a general term that describes an inflammation of the skin. There are different types of dermatitis, including seborrheic dermatitis and atopic dermatitis (eczema). Although the disorder can have many causes and occur in many forms, it usually involves swollen, reddened and itchy skin. (www.umm.edu/altmed/articles/dermatitis-000048.htm)

Identify and practice on common assessment techniques used to help in diagnosis of skin disorders.

diH20 acted as a negative control in the experiment, all cells, both in intrafollicular zone and in interfollicular zone stained purple. Cells stained brown in the negative control indicate non-specific staining.

There are many distinct clinical signs that are associated with IBC and are characterised by rapid progression. One of the most common clinical signs is erythema, where the skin of the breast takes on a red or pink patchy appearance. Erythema is also associated with a release of heat and an increase in size of the affected breast (Figure 1). IBC and the resulting edema also causes the skin to take on the appearance of orange peel (typically called peau d’orange), which is characterised by a dimpled texture to the skin. This is caused by the exaggeration of the hair follicle pits which are associated with edema (Robertson et al., 2015).

It appears that following an immunological event, auto-antibodies of mainly the IgG1 subclass are produced that target and bind an extracellular domain of the carboxyl terminus of the bullous pemphigoid antigen (BPAg2 – also called BP180). BPAg2 is found within the basement membrane (the zone between the epidermis and the dermis).

Emerged from the Greek word meaning, “blister,” Pemphigus is a combination of a potentially life-threatening autoimmune and Mucocutaneous disorder, gesticulated by intraepithelial blister formation (Kuriachan, 2015). Although the appearance may suggest otherwise, an interesting factor is that Pemphigus is not contagious by blood, fluids, or airborne aerosols (Kuriachan, 2015). Pemphigus is also not a genetic disorder. It is an exceptionally rare, autoimmune disease that affects a significantly confined percentage of the population. An autoimmune disease flourishes when your immune system, which guards your body against disease, decides your healthy cells are estranged (Roddick, 2016). This reaction threatens your immune system, and attacks

Endemic pemphigus foliaceus (PF), also known as fogo selvagem, is a skin autoimmune blistering disease due to acantholysis, the loss of adhesion among keratinocytes. PF is characterized by autoantibodies against desmoglein-1 (DSG1). These autoantibodies are found in patients’ sera as well as bound to their epidermal keratinocytes. The mechanism that allows sensitization to self antigens and result in the generation of pathogenic autoantibodies in pemphigus are not understood, although both environmental and genetic factors are likely to be involved [1-4]. Brazilian endemic form of PF shares similar clinical, histological and immunological features with the non-endemic form of PF seen in the USA and around the world. Pemphigus is endemic not

Invertebrates lack a complex clotting factor cascade that is found in humans. Instead horseshoe crabs have a group of proteins known as lectin (3). The function of Tachylectin-5A, which is produced by hemolymph, posses strong hemagglutinating activity against all types of human erythrocytes (3). It plays an important role in the recognition of invading pathogens. Tachylectin-5A serves to trigger the activation of the complement system and the activation of serine proteases (6).