Pertussis Synthesis

Decent Essays
I chose this discussion topic because I was curious about why the pertussis vaccine is not as effective as it once was, and wanted to understand more clearly if the reason was directly related to the composition of the vaccine itself. Through my research, I think I have a better grasp of the rationale for changing from the original to the present formulation and what changes were made to produce a desired, equivalent form. Adding aluminum intensifies the immune response through complex biochemical mechanisms, but primarily results in increased antibody production, further, incorporating it was necessary due to a using less potent antigen (Coffman, Sher & Seder, 2010). Not being a Biochemist, that is the best explanation I was able to derive
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