Pill Loss Investigation

Ensures all the pills are separated into the correct times as well as days. And

6. The solubility of the solids were tested using a micro tray, by placing them in water and oil to observe their polarity,

After reading several articles published on this subject, my position is that the pill manufacturer’s

Unfortunately, this topic affects a lot of people, taking away their freedoms. “Among them are… Zondenta McCarter, a sixty six year old woman, a first offender, poor and illiterate, suffering from diabetes, described as naive, trusting and childlike… sentenced to 8 years in prison.” (Schlosser, 4) The author explains that just because she used something once that she’s a dangerous criminal, but if she wasn’t apart of violent crimes she shouldn’t be getting such a harsh sentence. Mark Bennett interviewed some of the criminals, “18 were pill smurfers… single mothers… yet all of them face… sixty to 120 months.” (Bennett, 1-2) None of them were violent crimes, sadly, they get sentences that not only affect them but their families and the world.

Podcast “Race and Medline” talks about how some researchers started to test a drug to see if it can help with heart failure. After they asked the FDA to make this drug into a pill they said no because the research trial was too small. Then they started to think about

In November 2015 Beats by Dre released its first new speaker, Pill+, since its recall of Pill XL due to overheating issues. The Pill+, a tangible good, offers many benefits to its customers. Since Apple acquired Beats in 2014, the new speaker has incorporated some of Apple’s technology into it, such as the charger. The same Lightning cable charger users use for their iPhones can be used to charge the speaker (“Beats new Pill”, 2015). This speaker offers a battery life of twelve hours, which is seven hours longer than the company’s original speaker, the Pill and only takes three hours to charge. With the Beats Pill+ App, customers with both Apple and Android devices can unlock new features. In DJ mode, two users can simultaneously connect their phones to speakers, alternating playing music. (BeatsbyDre, 2016). Customers can also amplify their sound with the app by pairing two speakers wirelessly allowing the music to play from both speakers, which is an upgrade from previous versions that had to be “bumped” with NFC’s tap-to-pair technology (“Beats new Pill”, 2015).

The essence of our project is to create an affordable and secure pill dispenser, in order to improve proper medication adherence. Statistics on medication adherence prove it is an extremely prevalent issue, yet is not addressed nearly enough. This is a very solvable problem - most people practice poor habits when taking medications simply because they are unorganized. While researching potential topics, we realized even the cheapest dispensers to regulate intake of medications costed well over $100, which is rather expensive for most people. This is why we decided to take it upon ourselves to build an affordable dispenser. We will most likely gravitate sales towards the elderly, and those with Alzheimers and dementia.

Which has the higher potency? Which has higher efficacy? Please define positive and negative controls and state whether you think their choices fulfill those criteria.

Life never designs a line of control to limit man to certain boundaries. I found this hard truth acceptable when my life was stormed with many ailments. Many drugs I tried were of no avail; moreover the side effects were so severe eventually prescription medicine was averted by my organic system. The world of pharmacy is widely extended and reaches every part of the world, yet there is no company that can claim perfection. Of course, perfection is not easy to claim but in search of novelty and various means to reach the end these companies ignore the most important character. That being, the responsibility to take care of the drug user and to make sure he/she is not harmed by the pill.

In experiment two, the drug Panacetin was separated by a series of chemical reactions into its three components: sucrose, aspirin, and an unknown active ingredient, either acetanilide or phenacetin. The purpose of this lab was to determine what percentages of each component is present in the pain-killer. The initial step was to dissolve Panacetin in dichloromethane. However, sucrose is insoluble in dichloromethane because organic molecules are soluble in organic solvents, and dichloromethane is an inorganic solvent, so only aspirin and the unknown dissolved. By using gravity filtration, sucrose was filtered from the solution and 0.30g of solid was collected.

The study was performed to improve the compactibility and the biopharmaceutical performance of xylitol by improving its physicomechanical properties to make it better suited for tableting using direct compression. To this end, antisolvent crystallization technique was employed in the presence of various additives, i.e., polyethylene glycol (PEG), polyvinylpyrrolidone (PVP) and polyvinyl alcohol with a molecular weight (PVA22000) or 16000 (PVA16000) at varying concentrations (0.06%, 0.3%, 0.6% and 1.2%, w/v). The size and morphological changes induced by crystallization the in presence of the additives were studied. The dissolution performance of crystallized xylitols formulated with a model poorly water-soluble drug, i.e. indomethacin, in comparison to commercial xylitol were also evaluated.

Table: 40 Evaluation of Bilayer Tablets of Metoprolol Succinate SR and Hydrochlorothiazide IR after Stability Study at 40°C±2°C/75% ±5%RH

They may also increase the aqueous solubility of poorly soluble drug substance in the gastrointestinal tract and, as a result, the rate of dissolution of the active agent will increase. It should be noted that the surfactants should not interact with the drug substance as this may affect the dissolution rate of the drug substance. Example of surfactant include sodium lauryl sulphate (One of the most popular surface-active agent that improves the wetting properties of hydrophobic tablets), Cetylpyridine chloride, glyceryl monooleate etc.

Choudhary DR, patel VA , kundawala AJ, Formulation and evaluation of quick dissolving Film of levocetirizine dihydrochloride , Int J Pharma Tech ,2011;3 (1) :1740-1749

Choudhary DR, patel VA , kundawala AJ, Formulation and evaluation of quick dissolving Film of levocetirizine dihydrochloride , Int J Pharma Tech ,2011;3 (1) :1740-1749