Pioglitazone was also introduced in 1999 for treating type 2 diabetes mellitus. It improves glycaemic control and LDL cholesterol and also high-density lipoprotein (HDL) cholesterol ratio compared the placebo. It does not cause hepatotoxicity. There is no evidence that pioglitazone causes adverse cardiovascular effects. In fact, it has shown a beneficial effect on cardiovascular disease. Its combination with aliskiren (direct rennin inhibitor) is being considered as a possible therapeutic intervention for cardiovascular injury
Propranolol is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).
MR. David likewise takes atorvastatin (Lipitor); 10 mg every day, for hypercholesterolemia (hoisted LDL cholesterol, low HDL cholesterol, and raised triglycerides). He has endured this medicine and holds fast to the day by day plan. Amid the previous 6 months, he has likewise taken chromium picolinate,
In 2012, the phase 1 trials were published in The Journal of the American College of Cardiology. The phase 1 trials had two arms. Phase 1a were healthy subjects and phase 1b has subjects with hypercholestemia receiving stable statin therapy. The aim of this study was to evaluate the safety, tolerability and effects of AMG 145. Phase 1a had 56 subjects at 1 U.S. center, who were randomized to either get a single dose of placebo, 7mg to 420mg of AMG 145 subcutaneously or 21mg or 420mg via a one hour intravenous infusion. Percentagewise 69% of the subjects in the AMG 145 group experienced a treatment-emergent adverse event compared to 71% of the subjects in the placebo group. There was zero discontinuation due to adverse events in this arm of
This project seeks to provide a brief overview of what a new drug has to go through before it hits the streetsstarting with the manufacture, preclinical or clinical trials, documentation, registration, review, approval, marketing, &distribution; focusing on tests they have to hurdle. Another aim would be to identifya drug that binds itself to the SGLT2 & inhibits its function. The researcher has found that Dapagliflozin of the Gliflozin class of antidiabetic medications is anSGLT2 inhibitor. This paper will define keywords, explain the action, enumerate preclinical &clinical trials that have to be undergone before the FDA deems it safe for human consumption; with the ultimate goal of getting the product approved, marketed, &distributed in the US& elsewhere. There are no participants [animal or human] in this report. This
Selective serotonin reuptake inhibitors are utilized for their ability to reversibly block the reuptake of serotonin in the synaptic cleft. In order to understand the importance of these drugs, it is crucial to review the various regions of the brains that are influenced by serotonin and the implications of impaired functioning. A dysfunction in the hypothalamus region of the brain might lead to weight or appetite changes. Sleep disturbances are characterized by a dysfunction in the hypothalamus as well, along with the thalamus, basal forebrain, and prefrontal cortex. Thoughts of suicide and perceived feelings of guilt or worthlessness are associated with a dysfunction in the brain regions connected to our emotional well-being, including the amygdala, ventromedial prefrontal cortex, and orbitofrontal cortex. Psychomotor agitation is linked
Clozapine is a type of medicine known as atypical antipsychotic. Clozapine works in the brain, where it affects a neurotransmitter called dopamine. Neurotransmitters are chemicals stored in nerve cells, and are involved in transmitting messages between the nerve cells.
Pramipexole is a medication indicated for treating Parkinson's disease and restless legs syndrome (RLS). It is also used in treatment for cluster headache or to counteract the problems with low libido experienced by some users of SSRI antidepressant drugs. Pramipexole has shown robust effects on pilot studies in bipolar disorder. Pramipexole is classified as a non-ergoline dopamine agonist.
This particular research was driven by the demand of the regulatory guidelines that deals with reduction of risks. The cases of cardiovascular risks among patients are have been reported to increase in the recent days. The regulatory guidance require being presented for the cardiovascular outcomes that can be used in the therapies of type 2 diabetes treatment. However, the
There is growing concern that intense glucose lowering or the use of certain agents may be associated with adverse cardiovascular outcomes.
pantoprazole is a proton-pump inhibitor which is used to treat diseases caused by excessive release of stomach acid. It can be used to treat certain stomach and esophagus problems such as reflux and GORD
Methaqualone, is also referred to as Disco Biscuits, Down And Dirties, Jekyll-and-Hyde, Joe Fridays, Lemmon 714, Lemons, Lennon's, Lovers, Ludes, Mandies, Mandrake, Q, Qua, Quack, Quad, Quaaludes, Soaper, Supper, Vitamin Q, The Love Drug, Wallbangers, Whore Pills, and Sopor. This list of street names for the drug goes on and on.
Attached to your discharge papers you will find a list of the medications that the doctor wants you to take at home. The prescriptions have already been sent to your pharmacy and the pharmacy will deliver them all to your home this afternoon after 4:00 PM. I will go over each of your medications with you.
Gabapentin is an anti epileptic medication which is used to treat variety of conditions like epilepsy, neuropathic pain, hot flashes, diabetic neuropathy, post-herpetic neuralgia, and central neuropathic pain.
The disorder I chose from the text was panic disorder. Panic disorder is a form of anxiety. It’s a psychiatric disorder in which a sense of fear or apprehension arises frequently without a reasonable cause. The majority of physicians will prescribe a benzodiazepine, such as Xanax or Klonopin, to not only treat but also prevent their panic attacks from happening.
The debate to prescribe children psychiatric drugs has been going on for at least 57 years. 2,165,279 children are prescribed anti-depressants. 8,389,034 children are prescribed anti-psychiatric drugs. Although the medication may work, there are alternative treatments available until more research is done to determine more long-term side effects. A person’s brain does not develop fully until the age of 25. If you give a child a strong medication before psychological treatment to determine how mentally unstable the child is; the child may not be physical and mentally the same once he/she is adapted to the medication prescribed. This is why adolescents should not be given anti-depressant or anti-psychiatric