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Pneumocystis Pneumonia Research Paper

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Initially described as “plasma cell pneumonia”, pulmonary infection with the microorganism Pneumocystis jiroveci (formely known as Pnemocystis carinii) was first identified in malnourished infants (especially those in orphanages) at the conclusion of the Second World War. Today this disease, manifesting as a severe and often fatal pneumonia in immunocompromised patients, is of increasing importance to pediatricians and other specialists around the world.

Pneumocystis jiroveci is an opportunistic unicellular fungal pathogen that is widespread in the environment and thought to enter the body via airborne transmission. It also represents one of the several microorganisms that can cause life-threatening infection in patients with advanced HIV …show more content…

When organ transplantation became more pervasive in clinical medicine, it became evident that this type of pneumonia was linked to the immunosuppression used to prevent rejection of the organs.

In 1980s clusters of Pneumocystis pneumonia were observed in previously healthy men, which subsequently prompted a search of underlying cause of immunosuppression and eventually led to the first definition of the acquired immune deficiency syndrome (AIDS). And indeed, it turned out that a majority of individuals who develop Pneumocystis pneumonia have abnormal function and/or number of T lymphocytes.

Today, this type of pneumonia is still ubiquitous AIDS-defining diagnosis in North America, Europe and Asia, albeit it is mostly restricted to patients unaware of their HIV status at presentations, as well as to those intolerant or non-compliant in regards to antiretroviral …show more content…

Nevertheless, individuals with hampered immunity, and most notably those with CD4+ T cells (which play a pivotal role in mediating adaptive immune response to a plethora of pathogens) below 200 per μl of blood are considered at risk for the development of Pneumocystis pneumonia.

The research has shown that immunocompetent hosts are potential reservoirs of the fungus in population, as they can transfer it from one person to another when the distance is sufficiently close. Animal studies have demonstrated that even close-contact periods as short as one day can result in transferring Pneumocystis jiroveci from donors to immunocompetent recipients.

Except immunosuppression, other important risk factors for Pneumocystis colonization and Pneumocystis pneumonia are pulmonary disorders and infection with cytomegalovirus (CMV). The latter is due to the suppression of both helper T cells and antigen presenting cells by the virus, which inevitably alters host immune

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