Population Genetics

2030 Words9 Pages
In 1831, Charles Darwin, proposed a theory of evolution occurring by the process of natural selection. This has come to be known as the Theory of Natural Selection. Darwin worked on his theory for 20 years and after learning that Alfred Russel Wallace, another naturalist, had developed similar ideas, the two made a joint announcement of their discovery in 1858. Darwin published 'On the Origin of Species by Means of Natural Selection' in 1859, 28 years after he proposed his theory of natural selection. [1]
Darwin’s theory of natural selection states that evolutionary change comes through the production of variation in each generation and differential survival of individuals with different combinations of these variable characters. [2]
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She married Roelof Pasman on 12 November 1684 and they had 5 children before he died in 1695. In 1696 she married Pieter Robberts. They lived on a farm, Rustenburg, in the Stellenbosch district. A search through old manuscripts and documents revealed a map of the Cape of Good Hope, drawn between 1699 and 1713 by a cartographer named Valentyn, in which farms and the names of owners are marked. The farm on which they lived is still in existence today. They research into the two mariages of Sophie found that over 50 smaller affected families (who link up to form 4 very large Afrikaner families) was traced over 14 generations to common ancestors. Three of these are descendants of the marriage between Sophia v.d. Merwe and Roelof Pasman and the other large affected kindred stems from the later marriage of Sophia to Pieter Robberts. Accepting that affected individuals have descended from both these marriages, it is highly likely that Sophia v.d.M. carried the gene for Huntington's chorea.
The researchers searched through the earliest record relating to Sophie and the first arrival of the Dutch for evidence which might implicate either Sophia or her parents as carriers of the gene for Huntington's chorea. They were particularly interested in a disturbance of handwriting or history of antisocial behaviour, as these might indicate that the individual was affected. They believed Sophie was affected by Huntington’s Chorea as both her parents were able to sign their
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