Positron Emission Tomography

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3. Advantages and Setbacks of PET Positron emission tomography is primarily used in the area of medicine and research study. It has been influential in finding the cure for many diseases including Alzheimer’s and cancer. The positron emitting glucose analog, 18F-fluoro-2-deoxyglucose (FDG) has helped in the diagnosis, staging, and monitoring therapeutic response in various cancers. The metabolic imaging assessment is very helpful in providing important clinical data which in turn improves the patient management [6]. It is proved that the FDG-PET scan has better sensitivity, specificity, and diagnostic accuracy when compared to CT imaging in most cancer patients. The advantages of PET over other molecular imaging techniques are detailed in the following sections. 3.1 Advantages 3.1.1 Sensitivity The most important advantage of PET imaging is it's ability to exhibit a higher sensitivity (detecting and recording more number of emitted events) when compared to other methods such as SPECT, in which physical collimators are required to reject photons, which are not within a defined angular range. Hence the collimators have lower geometric efficiencies i.e. the percentage of detecting emitting photons (0.01%) [7]. 3.1.2 Coincidence Detection in PET Due to the annihilation event in PET, there is no need to employ physical collimators. The collimation is done electronically using the coincidence detection method. This in turn increases the angle of acceptance and hence the number of
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