Post Chemotherapy Essay

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Cancer is the one of those diseases which has high mortality rates in Pakistan. Most of these cases are diagnosed in advanced stages. Chemotherapy is one of the treatment components of cancer patients and electrolyte abnormalities are one of its common side effect. Electrolyte abnormalities are frequent and complicating element of cancer, these abnormalities may be due to underlying malignancy, a consequence of disease response or side effect of therapeutic agents, these side effects can be hazardous and fatal in some cases. This review presents the electrolyte abnormalities that can occur with the use of anticancer drugs. We have retrospectively reviewed the records of last 06 months of our admitted patients who were either admitted for longer regimes of chemotherapy or for the management of post chemotherapy side effects. In this review we have included total 110 patients out of which Breast, lung and colorectal cancers are leading malignancies followed by…show more content…
We found that, the patients who received Platinum-containing anticancer drugs they experience mainly hypokalemia, hyponatremia and hypomagnesemia, the ones who received chemotherapy with Alkylating agents have mainly developed hyponatremia, and those who received Vinca alkaloid containing regimes are also associated with hyponatremia. Patient who received Epidermal growth factor receptor monoclonal antibody inhibitors mainly experience hypomagnesemia, hypokalemia and hypocalcemia. Other, monoclonal antibodies, such as Cetuximab, mainly cause hyponatremia. All those patients who developed the drug related Tumor Lysis Syndrome their labs showed the incidence of hyperphosphatemia, hyperkalemia and hypocalcemia. We also found the incidence of hyponatremia and hypokalemia among those patients who received the chemotherapy with relatively newer agents like Novolumab. Some other previous international publications are also showed great similarity with our
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