Postpartum Depression Rat Model

Postpartum depression is one of the most common complications of childbearing with an estimated prevalence of 19.2% in the first three months after delivery (1). Depressive episodes (major and mild) may be experienced by approximately half of women during the first postpartum year (1). Characterized by depressed mood, loss of pleasure or interest in daily activities, feelings of worthlessness and guilt, irritability, sleep and eating disturbances (2), its etiology is multi-faceted and complex (3;4).

The research is discussing the effects of prenatal stress (PS) on the development of socioemotional symptoms as well as neurodevelopmental disorders. The study arises from existing literatures where a significant relationship has been established between prenatal stress and social deficits such as autism and attention-deficit hypersensitivity disorder among children and schizophrenia among adolescents. King et al. identifies exposures to environmental hardships and stressful events as the underlying factor in the development of PS (274). The aspect has a negative impact on the immune and endocrine system as well as neurological development (Charil et al. 56). Studies have revealed that PS affects several aspects of brain development in the fetal stage. It increases rate of cell death and reduces rate of proliferation in the hypothalamus-pituitary axis (Schoenfeld and Gould 15).

I believe that mental health is not well discussed, or known, in today’s culture. People could struggle with mental health daily and others could have no idea. There are many different types of mental health issues, and one specific issue that is rarely discussed is postpartum depression. Postpartum depression is a specific type of depression that new mothers can experience after the birth of their child. (Schacter, Gilbert, Wegner, Nock, 2012). The changing hormones a mother can experience directly after birth cause this condition. Postpartum depression can cause a mother to feel sad, guilty, and even experience thoughts of suicide. Postpartum depression may be discussed in the text, but the causes and even the treatments are not.

It is commonly believed that dropping levels of oestrogen and progesterone trigger the depression that many new mothers feel.

Postpartum psychiatric disorders, particularly depression, has become the most underdiagnosed complication in the United States. It can lead to increased costs of medical care, inappropriate medical care, child abuse and neglect, discontinuation of breastfeeding, and family dysfunction and adversely affects early brain development (Earls, 2010). Over 400,000 infants are born to mothers that are depressed. One of 7 new mothers (14.5%) experience depressive episodes that impair maternal role function. An episode of major or minor depression that occurs during pregnancy or the first 12 months after birth is called perinatal or postpartum depression (Wisner, Chambers & Sit, 2006). Mothers with postpartum depression experience feelings of extreme sadness, anxiety, and exhaustion that may make it difficult for them to complete daily care activities for themselves or for others (Postpartum Depression). The six stages of postpartum are denial, anger, bargaining, depression, acceptance and PTSD. These stages may affect any women regardless of age, race, ethnicity, or economic status. However only a physician can diagnose a woman with postpartum depression. It does not occur because of something a mother does or does not do, it’s a combination of physical and emotional factors. After childbirth, the levels of hormones in a woman’s body quickly drop; which may lead to chemical changes in her brain (Postpartum Depression). Unbalanced hormones may trigger mood swings.

Postpartum depression, which is the most prevalent of all maternal depressive disorders, is said to be the hidden epidemic of the 21st century. (1) Despite its high prevalence rate of 10-15% and increased incidence, postpartum depression often goes undetected, and thus untreated. (2) Nearly 50% of postpartum depression cases are untreated. As a result, these cases are put at a high risk of being exposed to the severe and progressive nature of their depressive disorder. (3) In other words, the health conditions of untreated postpartum depression cases worsen and progress to one of their utmost stages, and they are: postpartum obsessive compulsive disorder, postpartum panic disorder, postpartum post traumatic stress, and postpartum psychosis.

The prefrontal cortex is known to develop in the later periods of the prenatal stages when relating to myelination, cell growth and synaptic density (Kolb et al. 2012). Since it has a prolonged development with the expression of glucocorticoid (GC) receptors, the prefrontal cortex may be prone to early insults (Kolb et al. 2012). This study was also concluded in rats that showcased a relationship between maternal stress during pregnancy and reductions of dendritic spine densities in the prefrontal cortex (Kolb et al.

The Center for Disease Control estimates that 1 in 20 people suffer from depression (2014). Although widely recognized and somewhat easy to diagnose, depression is an ignored and almost hidden, disease. In women, the statistics are especially grim for those who are pregnant or were recently pregnant. A great number of women suffer from postpartum depression; an illness which is often overlooked, misdiagnosed and untreated. Postpartum depression (PPD) has been defined as an emotional disorder that occurs in an estimated 10-15% of all women after childbirth (Liberto, 2010). Postpartum depression not only impacts the mother, but can cause long-term psychological challenges for the baby and create emotional turmoil for all family members.

The brain develops in such a way that it leaves itself vulnerable to these negative influences. The prenatal brain develops an overabundance of neurons, some of which are then carefully eliminated before age 4 (5). In a process similar to this, the amount of synapses between neurons is built up during early childhood and then pruned back for the next 30 years of life (5). These two processes are both disturbed by elevated levels of stress hormones (5). The two centers of the brain with the most postnatal changes, including the growth of new neurons after birth, are the hippocampus, which is part of the limbic system, and the cerebellar vermis (6). The hippocampus is in charge of creating and retrieving memories, working together with the other parts of the limbic system, such as the amygdala, which records the emotions for each memory. The vermis controls the production and release of two of the catecholamine neurotransmitters, dopamine and norepinephrine (6). Both the vermis and the limbic system have higher concentrations of receptors for the stress hormone cortisol than anywhere else in the brain (6). Due to this fact, these still-developing areas are the most vulnerable to the damage done by elevated levels of stress hormones.

Postpartum depression is a mood disorder that causes extreme sadness, anxiety and exhaustion. The main cause of postpartum depression is believed to arise from the drastic change of hormones in the mother's body. After giving birth the production of estrogen and progesterone, the pregnancy hormone, is quickly stopped. The drop of progesterone can lead to chemical changes in the brain that may cause mood swings. Another cause of postpartum depression is the inadequate amount of sleep the mother gets. Sleep is essential for everyone but especially a mother that just gave birth. According to the National Institute of Mental Health, “Constant sleep deprivation can lead to physical discomfort and exhaustion…” (National Institute of Mental Health

Anxiety Depression Info Blog » 2005 » December » 06What causes postpartum Depression?No one knows for sure what causes postpartum Depression (PPD). Hormonal changes in a woman’s body may trigger its symptoms. During pregnancy, the amount of two female hormones, estrogen and progesterone, in a woman’s body increase greatly. In the first 24 hours after childbirth, the amount of these hormones rapidly drops and keeps dropping to the amount they were before the woman became pregnant. Researchers think these changes in hormones may lead to Depression, just as smaller changes in hormones can affect a woman’s moods before she gets her menstrual period.Thyroid levels may also drop sharply after giving birth. (The thyroid is a small gland in the neck

Activation of prefrontal 5-HT2A receptors is associated with elevated mood and improvement in several forms of cognitive function (Fisher et al., 2009; Vollenweider, Vontobel, Hell, & Leenders, 1999; Williams, Rao, & Goldman-Rakic, 2002). Estrogen can increase the density of these receptors in the brain in rats (Summer & Fink, 1995). In post-menopausal human women estrogen replacement therapy increases 5-HT2A binding in prefrontal areas of the brain (Kugaya et al., 2003).

Also, the HPA axis experiences a diminished response across different stressors in pregnancy. Cortisol levels have been found to decrease quickly after birth. Also, many areas of the body are dampened due to the diminished response experienced. These include more areas than the HPA axis, including a dampened blood pressure and a dampened heart rate (Glynn, Davis, Sandman, 2013). The Glynn et al. study found that administration of CRH during the third trimester actually produced no response in the women studied (2013). In addition to parts of the body being dampened, weakened psychological responses to stress have been shown. It is believed that these act as an adaptive value that protects the mother and benefits the child.

According to Morgan (2015), the neuroscience of depression has an emotional impact on many areas of the brain. The stressors in the hypothalamus pituitary adrenal axis initiate the release of the

A mother who struggles with depression post-partum is likely to expose her baby to more harmful effects. Gerhardt (2015) states that the baby of a depressed mother can find it difficult to cope with or get over stress, or they may be more fearful (p. 21). These babies also may respond to others with depression themselves, as their mother may be neglectful in their care (Gerhardt, 2015, p. 36). One of the reasons for this is because of their cortisol levels, which can fluctuate situationally. However, in infants this can affect their development (Gerhardt, 2015, p. 83) as well as their immune system (Gerhardt, 2015, p. 118), and is evidence that a mother with depression can have a significant impact on her child well beyond when the depression occurs. Additionally, Gerhardt (2015) notes that, “When they grow up, these babies of depressed mothers are highly at risk of succumbing to depression themselves.” (p.