Powder: Oral Water Soluble Drugs

1036 Words Feb 1st, 2018 4 Pages
Therefore, several potentially promising drug candidtates were rejected as pharmaceutical products due to ther poor solubilitty in GI fluid, poor dissolution in GI tract, low systemic absorption and thus poor oral bioavailability (therapeutically ineffective) (Hörter and Dressman, 2001). Therefore, enhancing the aqueous solubility and dissolution rate of poorly water-soluble drugs is one of the major challenges in pharmaceutical industry.
The study was performed to improve the compactibility and the biopharmaceutical performance of xylitol by improving its physicomechanical properties to make it better suited for tableting using direct compression. To this end, antisolvent crystallization technique was employed in the presence of various additives, i.e., polyethylene glycol (PEG), polyvinylpyrrolidone (PVP) and polyvinyl alcohol with a molecular weight (PVA22000) or 16000 (PVA16000) at varying concentrations (0.06%, 0.3%, 0.6% and 1.2%, w/v). The size and morphological changes induced by crystallization the in presence of the additives were studied. The dissolution performance of crystallized xylitols formulated with a model poorly water-soluble drug, i.e. indomethacin, in comparison to commercial xylitol were also evaluated.
Materials and Methods…