Pre Implantation Genetic Diagnosis (PGD)

Preimplantation genetic diagnosis (PGD) is a form of genetic testing. It is similar to the screening of abnormal chromosome count only used to test for genetic diseases. The fertility institutes have used this to take gender selection to the next level. Stating that this has a greater than 99,9% success rate.

A Preimplantation Genetic Diagnosis (PGD) is a test that “allows future parents to detect genetic defects that cause inherited disease in human embryos before they are implanted.” One of the most ethical questions that one might ask before considering the PGD is whether the benefits of genetic knowledge outweigh harmful effects that occur to the embryo? Is it really worth manipulating embryos genes in order to achieve the desire of the parents? Often times we have to take into considerations the risk and benefits of each situation. I believe that the PGD test should be only be done to detect genetic defects, but it should not be used to manipulate genes in order to make what to them is a “perfect” child. As stated in our text, “ In the united Kingdom alteration of an embryos genes, even for gene therapy or cloning embryos is illegal.” By manipulating genes its like going against Gods wishes. In the eyes of God every person that comes into this world is equally seen as a human being because they are all created in “ the image of God.” In this case the parents should not be allowed to manipulate the genes of their unborn child just to accommodate to their

PGD is known as pre-implantation genetic diagnosing. I do not think it is ethical to design and conceive a child that meets specific genetic requirements. I do not feel that this is an ethical reason to conceive a child. Rather, I believe all children should be seen as blessings or gifts, not sacrificial genetic progeny.

United States genetic centers now offer DNA tests for over 30 or 40 of the more commonly inherited disorders. Those including cystic fibrosis, susceptibility to breast cancer, X syndrome, Huntington’s disease, Duchenne muscular dystrophy, and many other various disorders (Golden). Also, with recent developments, couples are able to have a pre-implantation genetic diagnosis (PGD). This procedure allows the testing of genetic disorders before germination. It consists of “petri-dish” testing of sperm and egg cells donated by the soon to be parents. This procedure prevents the idea of abortion, for if genetic problems occur, you are not destroying a fetus, but simple flushing away embryo cells.

One advantage is the ability to reduce the risk for diseases. Through procedures like pre-implantation genetic diagnosis (PGD), one can inspect embryos created by in vitro fertilization (IVF) for many genetic conditions (Macklin, 2014, para. 1). While this process can be extremely beneficial ensuring the health of future generations, it can be misused in many ways.

Pre-implantation Genetic Diagnosis (PGD) is a reproductive technology in which, embryos are genetically analysed, before either being implanted into the uterus or discarded. It is most commonly used to avoid genetic diseases. Many ethical issues have been raised due to the increasing use of this technology. Eugenics is the process of enhancing the gene pool, for the improvement of humanity. One objection to the use of PGD technology is that it is unethical as it will lead to negative outcomes associated with the past eugenic movement.

What is Preimplantation Genetic Diagnosis? It’s basically were two parents have a child with a severe disease, they then make a second child to use as spare parts for the first. Also, is Preimplantation Genetic Diagnosis even an ethical choice? I suggest regulations to ensure abuse of this method is kept to a minimum

Pre-implantation genetic diagnostic testing is a technique that is used to identify and prevent genetic defects in the embryos of mothers through in vitro fertilization before pregnancy. The term “designer babies” is what is used to describe the result of this procedure. Preimplantation genetic diagnosis can cause new issues to arise through society, morality and even science, thus this procedure should be prevented. As these certain issues of society, morality and science combine together, it can lead a negative ripple effect on humanity.

PGD is performed with IVF and followed by genetic screening for mutant gene. IVF stage, eggs are collected and fertilized by sperm in the laboratory to produce Zygotes. Then, these Zygotes carry on to growing in the laboratory for 3 days until reached eight cells stage. Biopsy of embryo is performed and extracted blastomere from each 6-8 cell stage embryo. Then, cell undergoes genetic screening for mutant gene. Un-carrier and unaffected embryos are transferred into mother’s uterus with confident no CF mutant gene for ensuring a quality of life for baby (Destouni, 2016).

The Ovation Fertility Las Vegas genetics lab is proud to offer preimplantation genetic screening, PGS

Preimplantation genetic diagnosis (PGD) involves the use of genetic screening mechanisms such as Fluorescent In Situ Hybridization (FISH) or Comparative Genomic Hybridization (CGH) to help identify genetically abnormal embryos and improve healthy outcomes.

The procedure is repeated for each blastomere and the "disorder-free" cells are returned to the blastocyst for further incubation and later implanted into the mother.3 Micromanipulation mimics the purpose of other genetic diagnosis approaches like amniocentesis or chorionic villus sampling.5,4 In these procedures a sample of the amniotic fluid and/or the placenta are taken during pregnancy for genetic diagnosis. If signs of genetic abnormality exist, pregnancy might be and usually is terminated. What types of genetic abnormalities can PID screen for? First of all, only high-risk cases are tested, meaning either one (25 percent risk) or both parents (50 percent risk) is/are known carriers or persons with the disease. Furthermore, conditions must be pre-confirmed and studied before the procedure can be done because there is such a little amount of sample (cells) test. Therefore, there is a limitation on the capability of the procedure to effectively weed out genetic irregularity.3 The following genetic disorders may now be prevented using the PID method:

Data taken from the CDC states that every 4 ½ minutes a baby is born with a birth defect

The first stage is genetic counseling by a genetics specialist, who, working closely with a clinician, will inform the couple whether the aforementioned techniques are recommended in their case.

In the United States, an estimated 2.3 million couples are considered infertile [Wekesser, 1996]. This creates a large need for infertility specialists and clinics specializing in fertility treatments. With the quickly advancing field of rep roductive services and the quest for creating better, healthier babies, a new service called Preimplantation Genetic Diagnosis (PGD) is being offered in conjunction with In vitro fertilization.