Pregnancy Induced Hypertension

1243 Words5 Pages
METHYLDOPA IN THE MANAGEMENT OF PREGNANCY INDUCED HYPERTENSION
Contents
Introduction
Risk factors for the development of hypertension in pregnancy
Endothelial dysfunction- a key mechanism in pathogenesis of preeclampsia
Management of hypertension in pregnancy
Methyldopa in management of hypertension in pregnancy
Effects of methyldopa for hypertension in pregnancy- evidence based studies
Summary
References
Introduction
Pregnancy induced hypertension (PIH) is defined as diastolic blood pressure >90mm Hg and systolic blood pressure >140mm Hg. It is a syndrome with either pre-eclampsia-eclampsia or gestational hypertension (figure1). (Sharma). Between these conditions Pre-eclampsia Is associated with higher mortality and morbidity rates in both mother and fetus and causes complications in 3% to 8% of the pregnant women (Jennifer), .The underlying pathogenesis for the development PIH is not clearly defined granger). Many studies hypothesized preeclampsia is mainly due to placenta ischemia leading to maternal endothelial dysfunction.(granger, granger). Although there are standard guidelines for the treatment of hypertension in non-pregnant patients but treatment modalities for treating hypertension in pregnant patients is not clearly defined (mgee) .Anti-hypertensive drugs remain the mainstay of treatment of PIH. Methyldopa, a centrally acting antihypertensive drug is a drug of choice for the treatment of PIH as it is most effective and well tolerated.(Sharma)

Pre-clampsia
Get Access