Prevention Of Cancer Of Uterus / Cervical Cancer With The Human Papilloma Virus

1250 WordsDec 3, 20155 Pages
Florence F. Odekunle BINF 5130 Term Paper Fall Semester 2015 Prevention of Cancer of Cervix/ Cervical Cancer with the Human Papilloma Virus (HPV)-16/18 L1 Virus-like Particle Vaccine Introduction In this paper, I would like to critically review the article titled “Sustained efficacy up to 4.5 years of a bivalent L1 virus-like particle vaccine against human papillomavirus types 16 and18: follow-up from a randomized control trial” that was written by Harper, Franco, Wheeler, Moscicki, Romanowski, Roteli-Martin, Jenkins,Schuind, Clemens and Dubin and published in 2006. Additionally, few other studies are examined to provide background information on the topic.…show more content…
One type of adenocarcinoma is clear cell carcinoma, which is correlated with in utero diethylstilbesterol (DES) exposure. Very rarely a sarcoma or lymphoma of the cervix is found (Bosch et al. 2008). Human papillomavirus (HPV) types 16 and 18 are most commonly implicated in cancer of the cervix, other subtypes are 31, 33, 35 45,51,52,58 and 59 (Franceschi et al.2003). The association between HPV and cervical cancer is unique; no other major human cancer has a single necessary cause (Franceschi et al.2003). The relative risk of cervical cancer after infection with HPV, as indicated by the results of case control studies, is the strongest causal relation in cancer epidemiology identified to date (Bosch et al. 2002). The establishment of the link between HPV and cervical cancer has provided the impetus for research into prophylactic vaccination against the most common HPV types associated with the disease: HPV 16 and HPV 18. One of such studies was on sustained efficacy up to four and half years of a bivalent L1 virus-like particle vaccine against human papillomavirus types 16 and18: follow-up from a randomized control trial by Harper et al (2006). The following section provides the research aims/goals, the specific questions that were asked, the method used to address the questions, findings from the study, implications of the findings to healthcare practice and delivery and finally concluding remarks will be presented.
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