Processed Baby Foods, Cereal Products, Fruits Juices, And Canned Vegetables

2145 Words May 13th, 2016 9 Pages
Furanisproducedinawidevarietyofheat-treatedfoodsviathermaldegradation.Furancontaminationisfoundtoberelatively high in processed baby foods, cereal products, fruits juices, and canned vegetables. Several studies have demonstrated that furan is a potent hepatotoxin and hepatocarcinogen in rodents. However, few studies have investigated the toxic effects offuraninthetestis. Inaddition, theexact mechanism(s) bywhichfuranexerts toxicity inthetestis hasnot been fully elucidated. In this study, we investigated the potential of furan exposure from weaning through adulthood to induceoxidativestressinadultrattestis,aswellasthepotentialofgarlicoil(GO)toamelioratetheinducedtoxicity.Our results reveal that furan administration significantly reduced serum testosterone levels and increased the levels of malondialdehyde (MDA); furthermore, furan administration decreased significantly the enzymatic activity of testicular antioxidants,includingglutathione(GSH),superoxidedismutase(SOD),andcatalase(CAT)andinducedhistopathological alterationsinthetestis.GOco-administrationamelioratedthereductionintestosteronelevelsanddramaticallyattenuated the furan-induced oxidative and histopathological changes. In addition, Go significantly down-regulated the increased caspase-3 and cytochrome P4502E1 (CYP2E1) expression in the furan-treated testis. To the best ofourknowledge, this study is the first to demonstrate the furan-induced oxidative changes in the adult rat testis and the protective role of GO to…

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