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Prodromal Phase

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Three clinical stages have been defined in the clinical evolution of EGPA. The typical prodromal phase includes allergic rhinitis and asthma (usually without family history of atopy) that can be protracted for many years. The second involves peripheral eosinophilia and eosinophilic tissue infiltration. The feature of the final phase is systemic vasculitis with multiorgan pathology including cutaneous, cardiac, pulmonary, gastrointestinal, musculoskeletal, central, and peripheral nervous system and renal disease. If it is left untreated, it can be fatal (8). Cardiac, renal, gastrointestinal, and central nervous system involvement causes significant mortality (9). Most reported causes of death in children with EGPA are cardiac failure due to
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