Progeria Essay

950 Words4 Pages
Progeria Progeria is a disease of children that produces rapid aging. The exact cause of progeria is unknown, although a hereditary component may be involved. Progeria results in rapid aging of children, beginning with growth failure during the first year of life. Progeria is a rare condition but has come into public awareness because of its startling symptoms and the appearance of several affected children in movies on national television.The children are small and thin with disproportionately large appearing heads, baldness, wizened narrow faces, and old-appearing skin. Children with progeria develop early atherosclerosis. The average lifespan is the early teens, although several have…show more content…
Dyck in 1987 reported coronary artery bypass surgery and percutaneous transluminal angioplasty in a 14-year-old girl with this disorder. Recessive inheritance was suggested by the report from Egypt of affected sisters, children of first cousins. Paterson, in 1922 recorded the cases of two possibly affected brothers, photographs were not published and the diagnosis is not completely certain. The full report was simply the following: A boy, aged 8 years. Condition has been present since birth. The father and mother are first cousins. There are 4 children in the family, the girls are unaffected, both boys are affected. The senile condition of the skin and facies should be noted. The vessels show arteriosclerosis.(There is almost complete absence of subcutaneous fat.). Erecinski described photographically typical progeria in 2 brothers, and among the 9 offspring of 2 sisters, Rava in1967 found 6 affected. Khalifa in1989 described a consanguineous Libyan family in which 2 males and 1 female in 2 sibships related as cousins had seemingly typical Hutchinson-Gilford progeria. Repeated nonhealing fractures were the presenting manifestation in the proband. Maciel in1988 reported an inbred Brazilian family in which presumed Hutchinson-Gilford progeria had occurred in members of 2 sibships related as first cousins once removed. Although autosomal recessive inheritance
Open Document