Properties of T Regulatory Cells in Mutiple Myeloma

566 WordsFeb 4, 20182 Pages
This study explores the prevalence, role, and suppressive properties of T regulatory cells (Treg) in multiple myeloma (MM) patients as compared to healthy individuals. This is accomplished by analyzing peripheral blood and bone marrow Treg cells of premalignant and malignant MM patients with the use of flow cytometry. Treg, CD4 T, and lymphocyte cells in MM patients and healthy volunteers are also evaluated for their suppressive property. This was accomplished by testing effects of cyclophosphamide, thalidomide plus dexamethasone (CTD) upon cells, before and after treatment. A total of 25 patients were analyzed in this study. The results showed elevated frequencies of Treg cells in newly diagnosed and relapsed MM patients as compared to healthy volunteers. The proportion of naive and activated Treg cells were also higher in MM patients than healthy volunteers. Functional studies demonstrated no significance of inhibitory function between MM patients and healthy volunteers. There was, however, significant increases of Treg cells with clinically adverse effects (ie. hypercalemia, low normal plasma cell count, and IgA myeloma subtype) in MM patients as compared to the control. It was also observed that MM patients with ≥5% of Treg cells had inferior time to progression (TTP). While the CTD treatment significantly decreased Treg and CD4 cells, it was still not as low or lower than pre-treatment level. All in all, this study’s results suggest a causal link between elevated level

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