Protein : Essential Pathway For Ebola Virus

Ebola was named for a small river near Maridi, Sudan. Since Ebola first appeared in 1967 there have been over 100 cases of Ebola with more than 50% of the patients dying within days of their acute symptoms. Ebola is classified as a biosafety level four agent because of its extreme pathogenicity and the lack of a vaccine or antiviral drug. Ebola virus (Zaire ebolavirus); Sudan virus (Sudan ebolavirus); Taï Forest virus (Taï Forest ebolavirus, formerly Côte d’Ivoire ebolavirus); and Bundibugyo virus (Bundibugyo ebolavirus). The fifth, Reston virus (Reston ebolavirus), has caused disease in nonhuman primates, but not in humans. Ebola has spread between countries starting in Guinea then spreading across land borders to Sierra Leone and Liberia, Nigeria, USA, Senegal and Mali. Ebola has been presented for more than 35 years; however, the largest outbreak began in West Africa in March 2014. Ebola was previously reported in: Nigeria, Senegal, Spain, United States, Mali, and United Kingdom. However, there are no current cases of Ebola in these countries. There were four people who were diagnosed with Ebola in the United States. The two brought ebola into the country while the other two contracted the disease after caring for an Ebola patient in the United States. One man however died from the disease and the other three recovered and are now free of Ebola. Most of these cases were due to people traveling from a country where ebola was present. This outbreak cause severe and

* The Zaire virus, formerly named Zaire Ebolavirus, has the highest case-fatality rate, up to 90% in some epidemics, with an average case fatality rate of approximately 83% over 27 years. The first outbreak took place on 26 August 1976 in Yambuku.

Currently, Ebola is mainly being spread in West Africa. So far, about 4,000 to 5,000 people have been infected with Ebola. Ebola is spreading throughout West Africa because of the hygiene and culture in the countries in that region. “To stop the spread of Ebola, the World Health Organization is coordinating the construction and staffing of treatment centers across Liberia, Sierra Leone and Guinea.” -New York Times.

The filovirus Ebola consists of 4 families: Marburg, Ebola Zaire, Ebola Sudan, and Ebola Reston. It is a rather simple virus in structure; each contain a single strand RNA strand and 7 different proteins, 3 which are only slightly understood and 4 that are completely unknown. The virus harms the immune system like the HIV virus, but Ebola causes an explosive attack. The virus is associated with the measles and mumps family, pneumonia viruses, parainfluenza viruses which include colds, and respiratory system related viruses. Unlike common viruses which are ball-shaped, Ebola’s shape represents that similar to a shepherd’s crook, a long snake-like thread that looks like a worm. Because the Ebola virus has a distinct structure, it has been classified as a “thread virus” in its own family of viruses, the filoviruses.

Ebola Virus is a serious transmitted disease by both humans and animals. The disease first appeared in 1976 in 2 simultaneous outbreaks, one in Nzara, Sudan, and the other in Yambuku, Democratic Republic of Congo. The latter occurred in a village near the Ebola River, from which the virus received its name. Ebola Virus is a member of the negative stranded RNA viruses known as filoviruses. There are currently, five different strains of the Ebola Virus including, Zaire (EBOV), Sudan (SUDV), Bundibuguyo (BDBV), Taï Forest (TAFV) and Reston (RESTV). Each of the strains of the virus are very closely related including Reston which only effects animals. Yet, Ebola Zaire is the most highly virulent subtype, often leading to death. All of the different types of the virus are extremely dangerous and often cause death if untreated.

1) Ebola Virus- Belongs to the family Filoviridae. It has a single-stranded -sRNA genome, so it uses a RNA polymerase to create the +sRNA template, which acts as mRNA inside the host cell. The envelope is made up of peptidoglycan; the structure is made up of 7 structural proteins and 1 non-structural protein. This means it is an enveloped and susceptible to the outside environment. The Ebola virus replicates in Monocytes, Macrophages and Dendritic Cells. When the Ebola virus is ready to leave the host cell it buds out and takes part of the cell membrane with it. Ebola has an incubation period of 8-10 days. (CDC)

Ebola was first discovered in 1976. The most deadly outbreak of this virus started in March 2014 and is still occurring. The virus can be transmitted by animals or humans and it is transferred by bodily fluids. The virus can take up to 3 weeks to appear and does not currently have a cure or vaccine. Although there is no cure or vaccine, the virus is treatable and death is not always the result (Nall).

The Ebola virus was discovered in 1976 near the Ebola River in the Democratic Republic of the Congo. However many doctors believe they outbreak may have started from the eating of bats and apes or other primates. The bat naturally holds the virus and primates catch it by eating the infected bush meat or eating anything the bat may have defecated on.

Ebola is one of the harshest and most deadly viruses in the world. It is extremely contagious, but only through close contact with infected people’s bodily fluids (WHO). Major countries that are affected with Ebola include: Guinea, Liberia, and Sierra Leone (WHO). 13, 700 people have been cursed with Ebola, and of those 5,000have not been able to fight it (Hanna and Fantz).

The recent Ebola outbreak in West Africa has so far left over 1,350 dead, making it the deadliest Ebola epidemic thus far. The virus is spread on contact with infected animals and humans, and carries anywhere from a 50 to 90 percent mortality rate. The death rate of the recent

Ebola is one of the deadliest viruses known to mankind! Ebola was originally named Ebola hemorrhagic fever due to its hemorrhagic nature. It is a rare but deadly disease caused by infection from an Ebola virus vector. Ebola can be contracted by humans and nonhumans such as monkeys, gorillas, and chimpanzees. The Ebola virus has been detected in blood and many body fluids, including: saliva, mucus, vomit, feces, sweat, tears, breast milk, urine, semen, and vaginal fluids (Willett 16). Ebola can linger in your body for several days after recovery in organs such as the testes, eyes and spinal column fluid because it is not easily reached by the immune system. Ebola can also live on the surface of an object for several hours; it can live in

Ebola, once transmitted to a human is referred as Ebola hemorrhagic fever, is an uncommon viral infection that deliberately targets every part of the human body with the exception of the skeletal system. When this lethal disease enters the host, it will first cause pain throughout the body and dramatically increase the body's temperature. Next, internal and external bleeding tends to occur, specifically form the face. After that, it will simply destroy the bodily tissue that holds the host's organs together. Aside from this, what the virus actually does and how it is transmitted, little to nothing is known due to the complex structure of the infectious disease, as there are five identified Ebola virus species. Four of the five affect humans

The worst Ebola outbreak began to spread in southern Guinea in December 2013 and its now severely affecting three world’s poorest countries: Guinea, Liberia and Sierra Leone. The unusual spread of the virus was down to many factors including intense mobility around the borders, dense population, poor healthcare, government distrust and lack of international response to the epidemic crisis.

The Ebola virus, which is native to regions of Africa, causes an illness resulting in severe bleeding, organ failure, and even death. Outbreaks in Africa and other regions occur often. The virus is transferred from person to person through contact with infected bodily fluids of sharing needles. Once contracted, a patient will experience sudden symptoms such as fever, headache, aches, chills, and weakness. As the disease progresses, the symptoms become more severe. The symptoms of later cases of Ebola include nausea, vomiting, diarrhea, red eyes, rashes, chest or stomach pain, cough, severe weight loss, and internal; bleeding. There is no medication that can effectively treat the disease. Care for Ebola patients may include

The Ebola Haemorrahagic Fever, or Ebola for short, was first recognized as a virus in 1967. The first breakout that caused the Ebola virus to be recognized was in Zaire with 318 people infected and 280 killed. There are five subtypes of the Ebola virus, but only four of them affect humans. There are the Ebola-Zaire, Ebola-Sudan, Ebola-Ivory Coast and the Ebola-Bundibugyo. The fifth one, the Ebola-Reston, only affects nonhuman primates. The Ebola-Zaire was recognized on August 26, 1976 with a 44 year old schoolteacher as the first reported case. The Ebola-Sudan virus was also recognized in 1976 and was thought to be that same as Ebola-Zaire and it is thought to have broken out in a cotton factory in the Sudan. The Ebola-Ivory Coast was