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Psychological Effects Of Cocaine

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As mentioned, cocaine is a substance that increases levels of nervous activity within the body. There are multiple routes of administration including orally, intravenously, intranasally, or one can smoke this substance (Maisto et al., 2013). Smoking cocaine achieves a higher concentration far more quickly than through the intranasal route and is associated with greater tendency for dependence (Kiluk, Babuscio,Nich, & Carroll, 2013). Once the cocaine is administered, and depending on the form of administration, there is usually a lag in time before the user begins to feel the effects of the drug. These effects include, but are not limited to, increased heart rate, blood pressure, and respiratory rate, blood flow decreases to the internal organs and increases to the large muscle groups and the brain, body temperature is elevated, pupils are dilated, and cocaine acts as an appetite-suppressant (Maisto et al., 2013). …show more content…

According to Beuming and colleagues, the binding site for cocaine is deeply buried between transmembrane segments 1, 3, 6, and 8, and overlaps with the binding sites for the substrates dopamine (Beuming, Kniazeff, Bergmann, Shi, & Garcia, 2008). Molecules of cocaine bind to the sites on sending neurons that normally reuptake molecules of neurotransmitters (Maisto et al, 2013). This causes dopamine, norepinephrine, and serotonin to remain longer in the synaptic cleft which increases their typical mood-altering effects (Maisto et al.,

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