Pyoderma Gangrenosum Essay

Rheumatoid Arthritis or “RA” is an autoimmune disorder where the immune system mistakenly attacks its own body tissues. This disease affects the lining of joints causing pain and swelling. Eventually the swelling can lead to bone erosion and joint deformity. RA can happen to anyone at any age, but the majority of people who have to endure this disease are women over the age of 40.

Diagnostics to help determine this disorder would first be getting an x-ray done, a (ESR) erythrocyte sedimentation rate can be done to determine if there is any inflammation and in this case there would be an increase in the (ESR), also a (RF) rheumatoid factor is performed, this is a blood test to determine how much RF antibody is in the blood which is very helpful to determine if you have RA or an autoimmune disease, if there is an increase then there is most likely a chance of knowing that you have rheumatoid arthritis (MedlinePlus, 2013).

     Another type is Rheumatoid arthritis. It is what’s known as an inflammatory arthritis. It is the second most common form of arthritis, right behind osteoarthritis. It affects primarily the small joints in the hands and feet, causing crippling deformities. This is an arthritis that usually starts in middle-life or earlier. Estimates say one out of every hundred people, (females are two to three times as likely) suffer from it. It usually starts in the winter and after a common sickness, but it isn’t considered an infective arthritis. Nobody knows what causes rheumatoid arthritis. It could be some hereditary trait. Scientists think that rheumatoid arthritis may be an autoimmune disease (that means the body acts as though it were allergic to itself). The immune system gets mixed up and attacks normal joint tissue instead of the infection it is supposed to attack.

Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. While inflammation of the tissue around the joints and inflammatory arthritis are characteristic features of rheumatoid arthritis, the disease can also cause inflammation and injury in other organs in the

Main purpose of cellulitis treatment process is reduction of severity cellulitis infection, fast recovery, pain relieve, cure affected skin and prevention of recurrence - definition of treatment for cellulitis. In most cases healing process contains treatment with antibiotics drugs. Antibiotics are used orally or intravenous depending of severity of affected skin area. Period for using oral antibiotics (by mouth) is 10 to 14 days. In this period is crucial to take every single pill that doctor has prescribed, even later when you begin feel better .Treatment for cellulitis with intravenously antibiotics (IV) is recommended when we have more serious infection,in most cases lasts 3 to 5 days.

Gorham’s disease is an extremely rare musculoskeletal disease of unknown origin that is characterized by the uncontrolled production of distended, thin-walled vascular or lymphatic channels within bone, which leads to resorption and replacement of bone with angiomas and/or fibrosis and the destruction of bone (Lymphangiomatosis and Gorham’s Disease Alliance [LGD Alliance] 2016). This disease usually occurs in children or younger adults that are forty years or younger. Diagnosis and treatment is usually delayed due to the rarity of this disease and due to the fact that many physicians do not have the chance to learn about this disease (Patel, 2005). Because of the loss of the affected bone, the condition is also called disappearing bone disease, vanishing bone disease, and massive osteolysis. Osteolysis means the breaking down of bone. The word is broken up into bone (osteo) and breaking down or destruction (lysis) (LGD Alliance 2016). Fewer than 200 accounts of Gorham’s Disease are reported in the medical literature (National Organization of Rare Disease [NORD] 2008). The condition got its name when Gorham and his colleagues discovered two patients with massive osteolysis in 1954. In 1955, Gorham and Stout discovered further information on these cases and named the disease Gorham’s disease, sometimes called Gorham-Stout disease (Patel, 2005).

Rhematoid Arthritis – Is an autoimmune disease which can cause chronic inflammation of body`s organs, joints, and the surrounding tissue of the joints. It can

Rheumatoid Arthritis(RA) is the most common type of autoimmune arthritis. RA is a progressive and debilitating musculoskeletal disorder that affects the joints symmetrically, causing a range of systemic effects. What it causes is still not well known; nevertheless, findings of new research points towards a believe that it is triggered by a defective immune system, which causes the release of inflammatory chemicals. These chemicals cause damage to cartilage and bone, usually affecting the wrists, the joints of the hand, including the knuckles, the middle joints of the fingers and feet. While this condition can affect any joints, besides, important body organs such as the eyes and the lungs can also be affected by the inflammation that occurs as a result of this chronic condition. Only in America 1.3 million of people are affected by this ailment, and 75 % of them are mainly women. Its onset usually occurs between fourth and sixth decades; however, RA can occur at any age("Diseases And

Initially diagnosis of herpes simplex was entertained and herpes cultures were taken but the appearance of the lesions, the very marked pain that was associated with them, and the occurrence of these lesions in the setting of rheumatoid arthritis and diabetes all suggested a diagnosis of pyoderma gangrenosum. He subsequently, was hospitalized because of worsening respiratory failure and subsequently, was treated for pneumonia and what is probably some congestive failure. He improved from intensive treatment of these problems but developed further ulceration on his right medial thigh with two large undermining lesions. He now is currently being treated with prednisone at 20 mg per day down from previous 40 mg. He continues to have marked hyperglycemia with difficulty controlling his blood sugars partially because of the prednisone dosage. He is being treated now with a collagen wound healing ointment and he is making excellent progress. While hospitalized for his pneumonia and pulmonary decompensation, he was treated with Levaquin and clindamycin. But cultures from the skin lesions were never positive. A biopsy of the lesions has shown a lymphocytic, histocytic and neurophilic infiltrate without signs of

Rheumatoid arthritis is a chronic syndrome that is characterized by inflammation of the peripheral joints, but it may also involve the lungs, heart, blood vessels, and eyes. The prevalence of this autoimmune disease is between 0.3% to 1.5% of the population in the United States (Feinberg, pp 815). It affects women two to three times more often than men, and the onset of RA is usually between 25 and 50 years of age, but it can occur at any age (Reed, pp 584). RA can be diagnosed by establishing the presence of persistent joint pain, swelling in a symmetric distribution, and prolonged morning stiffness. RA usually affects multiple joints, such as the hands, wrists, knees, elbows, feet, shoulders, hips, and small

Laboratory: CK 41, aldose 5.7, CCP 5, rheumatoid factor 10.8, ANA negative, ANCA is less than 1:20, P-ANCA less than 1:20, hypersensitivity pneumonitis panel is negative, anti-Jo-1 is less than 0.2, scleroderma antibody is less than 0.2, IDE total 5. CBC within normal limits.

Bullous pemphigoid is a skin disease that causes blisters to form on the skin. The disease ranges in severity and can last for a long time. It can also come back months or years after it goes away.

RA begins with plasma cells overproducing rheumatic factors (RF) and antibodies to citrullinated protein antigen (ACPA). RF and ACPA can cause damage as well as activate macrophages, which play a large role in inflammation of the rheumatic synovium by drastically increasing the number of proinflammatory cytokines in the joint (Arend, 2001). Tumor necrosis factor alpha (TNF- α), interleukin-1 (IL-1) and interleukin-6 (IL-6) are the main cytokines involved in RA, which attract immune cells to the joints and cause tissue destruction (Arend, 2001). In addition, macrophages will also activate B and T cells via their MHC class II (Lee & Weinblatt, 2001). B and T cells are thought to play a role in the systemic aspects of RA but have an unclear function in synovial joints (Lee & Weinblatt, 2001).

Rheumatoid Arthritis is an autoimmune disease that attacks the musculoskeletal system. This means that certain cells of the immune system do not work properly and start attacking healthy tissues — the joints in RA. The cause of RA is not known. When inflammation occurs in the joint, immune cells release chemicals which attack the cartilage and bone, causing the swelling that leads to pain. This type of disease can cause many difficulties in the body itself. Such as pain, stiffness, swelling in joints, limited motion, loss of energy and appetite, low fevers, dry eyes and mouth, firm lumps at extremities and body discomforts. Rheumatoid arthritis mainly affects the small joints in the body like hands and feet. In rare cases, rheumatoid arthritis

Rheumatoid Arthritis is an inflammatory and autoimmune disease that occurs when your immune system mistakenly attacks healthy joints, causing horrific symptoms such as immense pain, swelling, stiffness, and loss of physical function (What is rheumatoid arthritis (RA)?). Joint pain which affects over seventy million Americans each year, can be discomfort, pain, or inflammation arising from any part of a joint, including cartilage, bone, ligaments, tendons, or muscles (Rheumatoid Arthritis.). It is very common in Rheumatoid Arthritis and Osteoarthritis, which is inflammation or pain from within the joint itself. It can be mild, causing soreness only after certain activities, or it can be severe making even limited movement, particularly bearing