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Rabies Is A Viral Disease

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Most humans, have come in contact with a dog, cat, and even wild animals or rodents. Some of us become owners of such animals that are then domesticated. Although, cute and human 's best friend, people are not well informed when it comes to caring for. Does your pet has all the necessary vaccinations? What if I ask you how much do you know about rabies?

Some think it comes from animals like pigs or cows. Others suggest it comes from sick dogs or cats, which are commonly domestic. The truth is, rabies has been in existence for over 4000 years and many countries around the world have had some exposure to it. Rabies is a viral disease that takes place in more than 150 countries around the world and it has been associated mainly with …show more content…

First of all, rabies virus ' structure consists of negative-sense, unsegmented, a rod which has the shape of a bullet, single-stranded, and enveloped RNA virus. It 's genome is based on a leader-sequence (LDR) of about fifty nucleotides which is followed mainly by five proteins such as phosphoprotein (P), nucleoprotein (N), glycoprotein (G), polymerase (L), and matrix protein (M). These proteins are synthesized and play a role with translation process which occurs on free ribosomes in the cytoplasm.

The infection process starts by the synthesis of the rabies virus encapsulated to the host cell membrane (adsorption). Interactions between the G protein and receptors from a specific cell surface may be involved. Once adsorption has occurred, the virus penetrates the host cell and makes its entrance to the cytoplasm by pinocytosis through coated pits made of clathrin. In the large endosomes, also known as cytoplasmic vesicles, a conglomeration of virions can be found. The viral membranes join the endosomal membranes to allow the releasing of viral RNP into the cytoplasm (uncoating). In order to enable replication of the virus, messenger RNAs (mRNAs) have to be transcribed owing to the fact that lyssaviruses have a linear single-negative-stranded ribonucleic acid (RNA) genome.

The incubation time period for rabies generally takes 30 to 90 days but it can take few as 5 days and extend up to 2 years or more after

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