Rabies Virus ( Rv )

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Introduction: Rabies virus (Rv) is a type species1 of the viral genus Lyssavirus from the phylogenetic family Rhabdoviridae. The morphology pertaining to Lyssavirus consist of a spiked viral envelop surrounding a protein matrix—protein M2—and an inner ribonucleocapsid3 complex containing the viral ribonucleic acid (RNA). The spiked appearance of the viral envelop is secondary to the presence of glycoproteins that line its outer surface. Lyssavirus maintains both a helical and a cubical symmetry, however, the cubic viral complex is most prevalent in mammals. Throughout the course of history canines, both feral and domestic, have been the world’s most influential vector for the spread of rabies. Records dating back to the Babylonian era, 2300 B.C., detail civilian penalties for deaths caused by their dogs biting other civilians. In 100 A.D. the Roman Empire, Greece and Crete fell victim to the rabies pandemic. It later spread through Great Britain in 1026, and reached the Americas in 1703. The growing threat of the Rv engendered an order to shoot all dogs on site around St. James, London in 1753. The canine genocide did not cease the dissemination of the Rv. Dr. Emile Roux, MD, and Dr. Louis Pasteur, PhD, isolated and studied the Rv in 1881. Understanding the mode of action of the Rv, Roux and Pasteur were able to synthesis a killed vaccination from dried spinal cord laden with viral particles in 1883. Pasteur holds the acclaim for the vaccine’s discovery, because he

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