Randomized Trial Of Metformin Vs Insulin

1399 WordsMay 2, 20176 Pages
1. 2. 3. 4. 5. Author, Title, & Year Authors Spaulonci, Bernardes, Trindale, Zugaib, Francisco Title Randomized trial of metformin vs insulin in the management of gestational diabetes Year: 2013 Authors: Kitwitee, Limwattananon, Limwattanon, Waleekachonlert, Ratanachotpanich, Phimphilai, Nguyen, Pongchaiyakul Title Metformin for the treatment of gestational diabetes: An updated meta-analysis Year 2015 Authors: Corbould, Swinton, Radford, Campbell, McBeath, Dennis Title Fasting blood glucose predicts response to extended-release Metformin in gestation diabetes mellitus Year 2012 Authors: Gandhi, Bustani, Madhuvrata, Farrell Title Introduction of metformin for gestational diabetes mellitus in clinical practice: has it had an impact? Year…show more content…
After excluding criteria that failed to meet inclusion criteria, eight studies were included in the final analysis Seventy-one women who had GDM at 24 weeks’ gestation but before 32 weeks using the Australian Diabetes in Pregnancy Society criteria. From May 2008 to April 2009, women with GDM were offered metformin as an alternative to insulin. Inclusion criteria included: diagnosis of GDM between 24-32 weeks of gestation, singleton pregnancy, no pregnancy complications and no documented intolerances from Metformin. 592 women with GDM were enrolled in the study. 299 did not receive metformin while 293 received metformin along with diet and exercise. A total of 200 pregnant women diagnosed with GDM. Group A (n=100) was treated with metformin, and group B (n=100) was treated with insulin. Independent and Dependent Variables Dependent Variable: Maternal outcome such as: frequency of preeclampsia, rate of C-section, maternal weight gain Neonatal outcome such as: 1- and 5- minute Apgar score, umbilical cord pH, macrosomnia, neonatal hypoglycemia. Independent Variable: Use of Metformin in the treatment of GDM vs insulin Dependent Variable: Maternal outcome such as: frequency of preeclampsia, rate of C-section, maternal weight gain Neonatal outcome such as: 1- and 5- minute Apgar score, umbilical cord pH, macrosomnia, neonatal hypoglycemia. Independent Variable: Use of Metformin in the treatment
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