Rapidly Progressive Alzheimer's Disease: A Case Study

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Rapidly Progressive Alzheimer's Disease: A Case Study Abstract We present the case of a male (JR) who initially presented with mild psychosis, memory problems, uncharacteristic apathy, persistent depressive state, and family reports of occasional agitation at the age of 69. The family had been overseeing homecare without medical supervision based on their own research and family history. A complete physical was performed and no major comorbid conditions were found. Laboratory tests revealed abnormally high total tau and ptau levels in the cerebral spinal fluid, low levels of β amyloid protein, and confirmed JR harbored the apolipoprotein E ɛ4 susceptibility genotype consistent with a maternal history of dementia. A baseline Mini Mental State Examination (MMSE) score was then established, indicating JR had mild/moderate dementia and focal neurological signs. At the end of the first year the MMSE score declined by 5 points and extrapyramidal signs were evident, but during the second year an additional 8 MMSE points had been lost and JR had to be placed into a nursing facility. Due to the rapid progression of JR's dementia further testing was performed for signs of Creutzfeldt-Jakob disease, which was negative. During the third year, JR passed away and the post-mortem confirmed the presence of Alzheimer's disease and the absence of prion disease. Introduction Rapidly progressive Alzheimer's disease (prAD) is fortunately a rare condition, yet common enough to warrant
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