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Raynaud's Phenomenon Analysis

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Raynaud’s phenomenon is an episodic vasospasm of the peripheral digital arteries and veins that is triggered by extreme heat or cold, emotional stress, or chemical stress such as exposure to polyvinylchloride1-3. It is characterized by a signature three-color progression of the fingers or toes starting with pallor and moving to cyanosis and ending with erythema as the digits are reperfused. Primary Raynaud’s phenomenon is having these attacks as an isolated symptom without any underlying conditions. Secondary Raynaud’s phenomenon commonly occurs in individuals with connective tissue disease, most often systemic sclerosis1,2. Treatment with phosphodiesterase-5 inhibitors such as tadalafil, sildenafil, and udenafil are effective at reducing …show more content…

Hormones may play a role in this condition due to estrogen worsening the endothelial dysfunction in the peripheral vessels in secondary Raynaud’s phenomenon. Attacks tend to increase in incidence during the pre-ovulatory period of the female menstrual cycle. Preventable risk factors include smoking, heavy alcohol consumption , occupational exposure to sustained vibration of the hands and contact exposure to polyvinylchloride. Other risk factors are malignancies, clotting disorders such as antiphospholipid syndrome, and nervous system diseases such as idiopathic peripheral …show more content…

This may be sufficient in individuals with a mild primary condition, but for those with more severe attacks and attacks secondary to connective tissue diseases, these lifestyle modifications may not be enough1. Secondary Raynaud’s phenomenon results in persistent small vessel damage which leads to digital ulcers that can be complicated with infections. These infections have the potential to become necrotic and gangrenous1. Therefore, the focus of this review is on treatment options to reduce the frequency, duration, and severity of primary and secondary Raynaud’s phenomenon attacks, as well as improve the quality of life of individuals suffering from this condition with the goal of educating providers on the safest and most effective

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