Reaction Paper On Dengue

797 Words4 Pages
Dengue is the one of the most dangerous diseases in the world today. With over 50 million people infected annually, the mosquito-borne virus has been identified by the World Health Organisation (WHO) as a public health emergency of international concern. Despite the biomedical war on Dengue, the disease has proven difficult to defeat. What is particularly dangerous about Dengue is its alarming adaptability to the human immune system and antivirals, allowing it to evolve and survive. Singapore, being in the South-East Asia and Western Pacific region which is home to over 70% of the world population plagued by the disease, is especially at risk to this unpredictable and tenaciously resilient disease.
This, however, is set to change with the
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She and her team at the Genomic Institute of Singapore (GIS) has pioneered research into applying NGS to Dengue virus, achieving a method to amplify the Dengue virus out of human blood samples and subsequent NGS analysis, of which leads to many applications. To understand this complex technology simply, sequencing can be imagined as arranging big basket of nucleatides in order to make sense of each and all of them. Dengue, which is a virus composed of 10 000 base pairs, consists in each type a single mutation each time it replicates. This arises when the virus folds in its protein form and its error-prone RNA-dependent RNA polymerase changes its nucleic base to behave differently with a host factor, thereby making it more pathogenic. NGS is therefore particularly useful as it allows scientists to pinpoint at which particular point there is such a nucleotide variant, which is important epidemiological information on the highly mutagenic virus. That position corresponds the method of translation for the virus, which is critical to the life cycle of the virus and how it responds to selective pressure in the environment to change. By looking at base changes, NGS ultimately enables scientists to track what the virus wants to do. This is essential information then allows scientists start at developing many
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