Recent Advances in the Understanding of a Fatal Brain Tumor: Glioblastoma
1982 WordsFeb 18, 20188 Pages
Recent advances in the understanding of a fatal brain tumour: Glioblastoma
Despite our extraordinary advances in understanding the pathophysiology, the battle against cancer is still far from being won. Humankind almost always stood helpless and unarmed against this nightmare named cancer. Among all types of cancer, malignant brain tumours are the one of the most dangerous kind, due to their location in the most vital organ of our body – the brain. Along with that, limited therapeutic options made them the cancers with grimmest prognosis.
Glioblastoma is an aggressive and the most fatal type of malignant brain tumour arising from the glial cells of the brain. Over fifty-one percent of the glial cell tomours are glioblastomas . Glioblastoma causes over 13,000 deaths every year and about 18,000 new glioblastoma cases are diagnosed annually . Glioblastomas are tumours of a special type of glial cells known as the astrocytes; hence they are a type of astrocytoma. WHO has subdivided astrocytomas into several grades [Table 1] according to their pathology. Glioblastoma or glioblastoma multiformae (GBM) is the highest grade of astrocytoma (grade IV) being the most aggressive of them.
Table 1. WHO grading of the astrocytoma.
Glioblastoma can be either primary or secondary depending on the key genetic mutations in the tumour, which also predict the survival of the suffering patients. Primary glioblastoma contributes to more than 90% of the glioblastoma cases, and arise