Reducing Alzheimer's Disease

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slowly increasing due to many factors including our better health care system, better diet and more sanitary living conditions. Due to this we are seeing an increase in age related illnesses such as dementia. The main form of dementia is Alzheimer’s disease, a neuroinflammatory disease, which causes impaired cognitive activity. There is currently no cure for Alzheimer’s disease and current treatments are only effective temporarily. Recently a study carried out by Kuti Baruch, Neta Rosenweig et al. looked at a novel way of treating the disease by studying the effects of Foxp3+ regulatory T cells. Their focus during this study was whether or not a reduction in the level of Foxp3+ would have a beneficial effect on Alzheimer’s pathology. (1-3)…show more content…
(1) In the 2014 Delphi consensus over 800,000 people were living with dementia, however there are many forms of dementia the most common of which is Alzheimer's disease. This currently affects more than 520,000 people in the United Kingdom with over 40,000 of these people being under the age of 65. (2,3) There is currently no cure for Alzheimer's disease and many who suffer from the disease go on to become dependent on care, either from family members or professional carer, as they are no longer able to go about their daily lives as they did before.(2) Damage or lesions to the brain are the main causes of Alzheimer’s disease; the two main causes of these lesions are neurofibrillary tangles and senile plaques. (4) These are commonly known as plaques and tangles and are caused by the build-up of two proteins. The plaques are a build-up of the protein beta-amyloid (β-amyloid) while the tangles are formed by the build-up of the protein tau, even though both are found in Alzheimer's disease only the β-amyloid plaques are unique to the disease and it is these plaques that are believed to be the primary cause of Alzheimer's.…show more content…
These drugs are used during early stages of Alzheimer's when symptoms are mild to moderate, however research has shown that these drugs do not reduce any of the underlying causes of Alzheimer's and they do not increase the time before a person with the disease could live without professional care. Due to this these treatments are mostly used in a palliative sense, they help reduce the symptoms but are not a cure and cannot remove the disease. (6, 7) Currently there is not a treatment that is focused on the cause of Alzheimer's, the plaques and tangles. (6) However research carried out by Kuti Baruch et al focused on targeting Foxp3+regulatory T cells and the effect this would have on helping clear the β-amyloid plaques, this research may lead to the creation of new treatment types that would be more than palliative in nature.
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