Relationship Between T Cell Regulation And Type I Diabetes
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Abstract The purpose of this study is to explore the relationships and mechanisms between T-cell regulation and type I diabetes by using NOD mice model. NOD mice can spontaneously develop a form of autoimmune diabetes which is similar to human Insulin-Dependent Diabetes Mellitus. T cells can destroy beta cells of the pancreatic islets which can produce insulin. Thus, by analyzing the development of NOD mice autoimmune diabetes to determine potential treatment for type I diabetes.
Introduction Diabetes mellitus is a group of metabolic diseases. There are different kinds of diabetes mellitus, but an abnormal blood sugar level over an extended time always can be detected from patients who have this disease. Type one diabetes mellitus also known as insulin-dependent diabetes, patients with this type of diabetes have pancreatic beta cells destruction causing absolute lack of insulin with a tendency to ketoacidosis. It can occur at any age, but more commonly occurs in young people. Patients with acute onset of metabolic disorders symptoms need insulin injections to survive. This type of diabetes including immune-mediated and idiopathic two subtypes. Immune-mediated diabetes often has one or more autoantibodies present, for example, islet cell antibodies (ICA), insulin autoantibodies (IAA) and glutamic acid decarboxylase 65 (GAD65) antibodies.
Previous studies have shown that killer T cells that protects us from bacterial damage plays a major role in the
cancers(22). Considerable up-regulation of miR-23a was reported by Meng and Gottardo in human bladder cancer and in malignant cholangiocytes compared to normal tissues. Furthermore, Mi et al. in their study showed that miR-23a was among several other miRNAs that have been differentially expressed between acute myeloid leukemia (AMLs) and acute lymphoblastic leukemia (ALLs). In addition, up-regulation of miR-23a/b along with miR-24 has also been identified in osteoblast cell line (20,21).
An exonic MiR-155
Table of Contents
I. Introduction to Type 1 Diabetes Mellitus
a. What it is
b. Prevalence and demographics
c. Treatment
II. Cognitive Outcomes: Mood and Memory
a. Memory
i. Neural Basis of Memory
ii. Cognitive Outcome of TIDM on Memory
III. Structural Brain Changes: MRI Studies
a. The Hippocampus
i. Purpose and Function of the Hippocampus
ii. Previous studies on T1DM and Hippocampal Volume
iii. The Cognitive Effects of T1DM on Hippocampal Volume
b. Other Brain Areas
IV. Conclusion
a
The human immune system has advanced to distinguish between and eliminate disease-causing microorganisms. Nevertheless, a symbiotic relationship has been developed with several species of bacteria that not only inhabit the gut, but also make up the natural commensal flora or microbiota. The microbiota, being essential in the breakdown of nutrients, helps prevent colonization by potentially pathogenic bacteria. Also, the gut commensal bacteria appear to be vital in the growth of an efficiently functioning
I. Introduction and Purpose
Diabetes mellitus, or simply diabetes, is a disorder in which the body is incapable of fully utilizing converted energy taken from food. There are three types of diabetes: type 1 or insulin-dependent, type 2 or adult on-set, and gestational diabetes (Webmd.com, 2014).
According to the American Diabetes Association, in 2011 there were approximately 25.8 million cases of diabetes in the United States, 7 million of which were undiagnosed, and an estimated 79 million
and Embryology, Faculty of Medicine, Menoufia, Egypt
a r t i c l e i n f o
Article history:
Received 3 August 2013
Received in revised form 17 January 2014
Accepted 31 January 2014
Keywords:
Ginger
Diabetes
Brain
Histology
Immunohistochemistry
s u m m a r y
Diabetes mellitus results in neuronal damage caused by increased intracellular glucose leading to oxidative
stress. Recent evidence revealed the potential of ginger for reducing diabetes-induced oxidative stress
markers. The aim of this study is
their ensuing management. The progression of atheroma consist of several cellular and molecular events with endothelial dysfunction, leucocyte recruitment and dispedesis, LDL transcytosis, LDL oxidation, recruitment and proliferation of smooth muscle cells, synthesis of extracellular matrix proteins, build-up of foamy macrophages as well as interplay of different cytokines. (Bisht et al, 2012).
Atherosclerosis known as the leading cause of death globally - has established much attention as to its origins
atheromas (Hansson, 2005). In models of experimental atherosclerosis, expression of
VCAM-1 has been shown to increase on endothelial cells overlying nascent
atheromas before leukocytes adhere to the arterial endothelium, and also mice
genetically engineered to express defective VCAM-1, have shown interrupted lesion
development (Cybulsky et al, 2001). Once the blood cells have attached, chemokines
produced in the underlying intima stimulate them to migrate through the interendothelial
junctions and
Background: Nonalcoholic fatty liver disease (NAFLD) is a metabolic disease commonly associated with obesity, type 2 diabetes, and inflammation-all features of insulin resistant syndrome. However, very limited data are available regarding the association of subclinical inflammation and insulin resistance with NAFLD in a prediabetic state. We, therefore, conducted the study to assess this relationship among this population.
Methods: We studied a cross-sectional analytical design of 140 [male/female, 77/63;
that can lead to action being taken to control or prevent the disease usually one of an infectious nature. (MedicineNet, 2015)
Disease Surveillance can range from common Food Bourne illnesses to extensive long-term surveillance on diseases such as Diabetes and Cardiovascular disease.
In New Zealand, The Institute of Environmental Science and Research (ESR), plays a vital role in Notifiable Disease Surveillance. The Health Intelligence Team at ESR prepare annual and monthly reports of the statistics
Anti-obesity effects of polyunsaturated fatty acids
Introduction
In recent years, obesity has become a significant health problem in industrialized countries such as the United States. Obesity is strongly associated with increased risk of developing type 2 diabetes mellitus, hypertension, dyslipidemia, coronary heart disease, and congestive heart failure. The World Health Organization has defined obesity as one of the top ten global health problems. High-fat diets containing large amounts of saturated fat