Renal Microvascular Complications Of Type 2 Diabetes Essay

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Renal Microvascular Complications of Type 2 Diabetes: Aetiology and Pathogenesis Abstract There have been a number of manuscripts reporting on the association of complications in type 2 diabetes with high glucose blood levels, high levels of C-Peptide, high advanced glycation end products (AGEs) and vascular cell adhesion molecule-1 (VCAM-1) and oxidative stress. In order to further investigate the aetiology and pathophysiology of renal microvascular complications in type 2 diabetes, papers were reviewed through 2000 using the NIH PubMed Literature Search System. Inclusion criteria were that manuscripts 1) be primary peer-review research article; 2) concisely explained, or investigated, the pathophysiology of renal microvascular complications in type 2 diabetes; 3) be published in English. High blood glucose levels and enhanced oxidative stress, found in both clinical and experimental diabetes, are thought to be the main cause of chronic diabetic complications. Advanced glycation end products (AGEs) resulted to be strongly correlated to renal microvascular complications via enhanced expression of adhesion molecules, including vascular cell adhesion molecule-1 (VCAM-1). Renal Microvascular Complications of Type 2 Diabetes: Aetiology and Pathogenesis Diabetes mellitus type 2 is a complex disease with
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