Renal Regulation of Blood Osmolarity

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Abstract: The experiment was done to demonstrate the effect of ADH on the volume and concentration of urine in order to demonstrate the control of ADH over blood plasma osmolarity. Since non-invasive methods were preferred the volume and concentration of urine was used in place of drawing blood. The results that we our anticipating are that ADH levels in the group of subjects that ingested the 6 gm. Of NaCl would increase over time in response to the increased osmolarity of the blood from all of the salt. Urine output would decrease and eventually the body would stabilize.

Purpose: In this experiment, renal regulation of osmolarity will be demonstrated through the use of urinalysis.

Materials and Methods: In this experiment,
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The purpose of executing this experiment was to essentially illustrate our body’s compensatory mechanisms via hormone regulation to maintain homeostasis. Osmolarity of bodily fluids need to be in their appropriate “normal ranges” in order for the body as a whole to maintain “normal or healthy” functions. A disruption of homeostasis will eventually lead to disease whether acute or chronic if the compensatory mechanisms within our bodies are not working appropriately. Although the kidneys are the focus of the action, renal regulation of osmolarity goes well beyond the kidneys. The hormones involved in the process are ADH, aldosterone, and the few involved in the renin-angiotensin system. Due to the fact that ADH was the target of our experiment, we will begin with the anatomy and physiology involved with ADH. The cell bodies of the supra-optic nucleus of the hypothalamus are the site of synthesis of ADH, and the site of the osmoreceptors that detect changes in blood osmolarity. The posterior pituitary is the site of release for ADH. When the osmoreceptors detect a change in osmolarity the number and intensity of the action potentials fired will change. An increase will cause an increase in action potentials fired from the supra-optic nucleus to the posterior pituitary via the infundibulum. Likewise, a decrease in osmolarity will decrease the action potentials fired. The synaptic vesicles of the posterior pituitary will then secrete the appropriate

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