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Renal Syndrome

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Renal System Lesch-Nyhan Syndrome affects the renal system, central nervous system, and in some cases the circulatory system. The cause of juvenile gout associated with LNS is the over production of uric acid or hyperuricemia. As the body continues to make too much uric acid the result is tophus or uric acid crystals. These crystals collect under the skin and between the joints as tophi (under the skin) (Fig. B) or between the joints causing gout (Fig C). There is also a present uric acid crystals in the urine, this is known as uric acid crystalluria (Fig D.), if the stones are large they can be large enough to get stuck traveling through the ureters to the bladder. “If a large stone gets stuck in the kidney or on its way to the bladder, it
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